Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386309189> ?p ?o ?g. }
- W4386309189 abstract "Subcutaneous adipose tissue (SAT) is a critical regulator of systemic metabolic homeostasis. Persons with HIV (PWH) have an increased risk of metabolic diseases and significant alterations in the SAT immune environment compared with the general population.We generated a comprehensive single-cell multi-omic SAT atlas to characterize cellular compositional and transcriptional changes in 59 PWH across a spectrum of metabolic health.Glucose intolerance was associated with increased lipid-associated macrophages, CD4+ and CD8+ T effector memory cells, and decreased perivascular macrophages. We observed a coordinated intercellular regulatory program which enriched for genes related to inflammation and lipid-processing across multiple cell types as glucose intolerance increased. Increased CD4+ effector memory tissue-resident cells most strongly associated with altered expression of adipocyte genes critical for lipid metabolism and cellular regulation. Intercellular communication analysis demonstrated enhanced pro-inflammatory and pro-fibrotic signaling between immune cells and stromal cells in PWH with glucose intolerance compared with non-diabetic PWH. Lastly, while cell type-specific gene expression among PWH with diabetes was globally similar to HIV-negative individuals with diabetes, we observed substantially divergent intercellular communication pathways.These findings suggest a central role of tissue-resident immune cells in regulating SAT inflammation among PWH with metabolic disease, and underscore unique mechanisms that may converge to promote metabolic disease." @default.
- W4386309189 created "2023-09-01" @default.
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- W4386309189 date "2023-08-30" @default.
- W4386309189 modified "2023-09-27" @default.
- W4386309189 title "Changes in subcutaneous white adipose tissue cellular composition and molecular programs underlie glucose intolerance in persons with HIV" @default.
- W4386309189 cites W1608236599 @default.
- W4386309189 cites W179857658 @default.
- W4386309189 cites W1968994034 @default.
- W4386309189 cites W1989823340 @default.
- W4386309189 cites W1989832114 @default.
- W4386309189 cites W1994809630 @default.
- W4386309189 cites W1995237219 @default.
- W4386309189 cites W1998925785 @default.
- W4386309189 cites W2003338662 @default.
- W4386309189 cites W2008381613 @default.
- W4386309189 cites W2010957046 @default.
- W4386309189 cites W2016168268 @default.
- W4386309189 cites W2016662511 @default.
- W4386309189 cites W2024408216 @default.
- W4386309189 cites W2025866303 @default.
- W4386309189 cites W2027768860 @default.
- W4386309189 cites W2029116768 @default.
- W4386309189 cites W2035579985 @default.
- W4386309189 cites W2041544510 @default.
- W4386309189 cites W2042007762 @default.
- W4386309189 cites W2053577233 @default.
- W4386309189 cites W2069248440 @default.
- W4386309189 cites W2074340664 @default.
- W4386309189 cites W2082595913 @default.
- W4386309189 cites W2087647782 @default.
- W4386309189 cites W2094558708 @default.
- W4386309189 cites W2110630581 @default.
- W4386309189 cites W2124376174 @default.
- W4386309189 cites W2127517680 @default.
- W4386309189 cites W2141189887 @default.
- W4386309189 cites W2141913238 @default.
- W4386309189 cites W2143055774 @default.
- W4386309189 cites W2145697808 @default.
- W4386309189 cites W2164898309 @default.
- W4386309189 cites W2165334726 @default.
- W4386309189 cites W2179438025 @default.
- W4386309189 cites W2281322842 @default.
- W4386309189 cites W2312340658 @default.
- W4386309189 cites W2317927199 @default.
- W4386309189 cites W2342679639 @default.
- W4386309189 cites W2377838799 @default.
- W4386309189 cites W2406250479 @default.
- W4386309189 cites W2536640519 @default.
- W4386309189 cites W2605810679 @default.
- W4386309189 cites W2606998831 @default.
- W4386309189 cites W2736000705 @default.
- W4386309189 cites W2739492614 @default.
- W4386309189 cites W2743361508 @default.
- W4386309189 cites W2778757093 @default.
- W4386309189 cites W2785085486 @default.
- W4386309189 cites W2791127176 @default.
- W4386309189 cites W2791407170 @default.
- W4386309189 cites W2804734969 @default.
- W4386309189 cites W2809310576 @default.
- W4386309189 cites W2809355409 @default.
- W4386309189 cites W2824445991 @default.
- W4386309189 cites W2891983638 @default.
- W4386309189 cites W2893679529 @default.
- W4386309189 cites W2908320623 @default.
- W4386309189 cites W2913202413 @default.
- W4386309189 cites W2921168633 @default.
- W4386309189 cites W2923258631 @default.
- W4386309189 cites W2942273685 @default.
- W4386309189 cites W2949177718 @default.
- W4386309189 cites W2951158909 @default.
- W4386309189 cites W2951799803 @default.
- W4386309189 cites W2953151710 @default.
- W4386309189 cites W2955261360 @default.
- W4386309189 cites W2968973364 @default.
- W4386309189 cites W2970751796 @default.
- W4386309189 cites W2972869264 @default.
- W4386309189 cites W2979917028 @default.
- W4386309189 cites W2980899793 @default.
- W4386309189 cites W2981900400 @default.
- W4386309189 cites W2984472267 @default.
- W4386309189 cites W2994702596 @default.
- W4386309189 cites W2997280954 @default.
- W4386309189 cites W2999416853 @default.
- W4386309189 cites W3006605298 @default.
- W4386309189 cites W3009370296 @default.
- W4386309189 cites W3009874104 @default.