FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386314624> ?p ?o ?g. }

• W4386314624 endingPage "2163" @default.
• W4386314624 startingPage "2147" @default.
• W4386314624 abstract "Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii (CRAB) are associated with high mortality with limited treatment. The aim of this study is to compare effectiveness and safety of colistin-based versus cefiderocol-based therapies for CRAB-BSI. This is a retrospective observational study enrolling patients with monomicrobial CRAB-BSIs treated with colistin or cefiderocol from 1 January 2020, to 31 December 2022. The 30-day all-cause mortality rate was the primary outcome. A Cox regression analysis was performed to identify factors independently associated with mortality. A propensity score analysis using inverse probability of treatment weighting (IPTW) was also performed. Overall 118 patients were enrolled, 75 (63%) and 43 (37%) treated with colistin- and cefiderocol-based regimens. The median (q1–q3) age was 70 (62–79) years; 70 (59%) patients were men. The 30-day all-cause mortality was 52%, significantly lower in the cefiderocol group (40% vs 59%, p = 0.045). By performing a Cox regression model, age (aHR = 1.03, 95% CI 1.00–1.05), septic shock (aHR = 1.93, 95% CI 1.05–3.53), and delayed targeted therapy (aHR = 2.42, 95% CI 1.11–5.25) were independent predictors of mortality, while cefiderocol-based therapy was protective (aHR = 0.49, 95% CI 0.25–0.93). The IPTW-adjusted Cox analysis confirmed the protective effect of cefiderocol (aHR = 0.53, 95% CI 0.27–0.98). Cefiderocol may be a valuable treatment option for CRAB-BSI, especially in the current context of limited treatment options." @default.
• W4386314624 created "2023-09-01" @default.
• W4386314624 creator A5012988587 @default.
• W4386314624 creator A5013725465 @default.
• W4386314624 creator A5029801352 @default.
• W4386314624 creator A5032978217 @default.
• W4386314624 creator A5038122617 @default.
• W4386314624 creator A5039431918 @default.
• W4386314624 creator A5040155298 @default.
• W4386314624 creator A5041061779 @default.
• W4386314624 creator A5043634620 @default.
• W4386314624 creator A5057747329 @default.
• W4386314624 creator A5064623578 @default.
• W4386314624 creator A5076746852 @default.
• W4386314624 creator A5081103796 @default.
• W4386314624 creator A5083851680 @default.
• W4386314624 creator A5088188399 @default.
• W4386314624 creator A5089103720 @default.
• W4386314624 creator A5090566753 @default.
• W4386314624 creator A5092434200 @default.
• W4386314624 date "2023-08-01" @default.
• W4386314624 modified "2023-09-28" @default.
• W4386314624 title "Cefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumannii Complex Bloodstream Infections: A Retrospective, Propensity-Score Adjusted, Monocentric Cohort Study" @default.
• W4386314624 cites W2110818436 @default.
• W4386314624 cites W2168458505 @default.
• W4386314624 cites W2548889063 @default.
• W4386314624 cites W2936039267 @default.
• W4386314624 cites W3092173712 @default.
• W4386314624 cites W3092383626 @default.
• W4386314624 cites W3181221663 @default.
• W4386314624 cites W3217749790 @default.
• W4386314624 cites W4200036649 @default.
• W4386314624 cites W4200250437 @default.
• W4386314624 cites W4206237086 @default.
• W4386314624 cites W4220764592 @default.
• W4386314624 cites W4282982557 @default.
• W4386314624 cites W4292506088 @default.
• W4386314624 cites W4296778070 @default.
• W4386314624 cites W4297964887 @default.
• W4386314624 cites W4321478399 @default.
• W4386314624 cites W4366607230 @default.
• W4386314624 cites W4367557556 @default.
• W4386314624 cites W4380998191 @default.
• W4386314624 doi "https://doi.org/10.1007/s40121-023-00854-6" @default.
• W4386314624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37653122" @default.
• W4386314624 hasPublicationYear "2023" @default.
• W4386314624 type Work @default.
• W4386314624 citedByCount "0" @default.
• W4386314624 crossrefType "journal-article" @default.
• W4386314624 hasAuthorship W4386314624A5012988587 @default.
• W4386314624 hasAuthorship W4386314624A5013725465 @default.
• W4386314624 hasAuthorship W4386314624A5029801352 @default.
• W4386314624 hasAuthorship W4386314624A5032978217 @default.
• W4386314624 hasAuthorship W4386314624A5038122617 @default.
• W4386314624 hasAuthorship W4386314624A5039431918 @default.
• W4386314624 hasAuthorship W4386314624A5040155298 @default.
• W4386314624 hasAuthorship W4386314624A5041061779 @default.
• W4386314624 hasAuthorship W4386314624A5043634620 @default.
• W4386314624 hasAuthorship W4386314624A5057747329 @default.
• W4386314624 hasAuthorship W4386314624A5064623578 @default.
• W4386314624 hasAuthorship W4386314624A5076746852 @default.
• W4386314624 hasAuthorship W4386314624A5081103796 @default.
• W4386314624 hasAuthorship W4386314624A5083851680 @default.
• W4386314624 hasAuthorship W4386314624A5088188399 @default.
• W4386314624 hasAuthorship W4386314624A5089103720 @default.
• W4386314624 hasAuthorship W4386314624A5090566753 @default.
• W4386314624 hasAuthorship W4386314624A5092434200 @default.
• W4386314624 hasBestOaLocation W43863146241 @default.
• W4386314624 hasConcept C126322002 @default.
• W4386314624 hasConcept C151730666 @default.
• W4386314624 hasConcept C167135981 @default.
• W4386314624 hasConcept C177713679 @default.
• W4386314624 hasConcept C17923572 @default.
• W4386314624 hasConcept C2776315533 @default.
• W4386314624 hasConcept C2777637488 @default.
• W4386314624 hasConcept C2779259085 @default.
• W4386314624 hasConcept C2779343474 @default.
• W4386314624 hasConcept C501593827 @default.
• W4386314624 hasConcept C50382708 @default.
• W4386314624 hasConcept C523546767 @default.
• W4386314624 hasConcept C54355233 @default.
• W4386314624 hasConcept C71924100 @default.
• W4386314624 hasConcept C86803240 @default.
• W4386314624 hasConcept C89423630 @default.
• W4386314624 hasConceptScore W4386314624C126322002 @default.
• W4386314624 hasConceptScore W4386314624C151730666 @default.
• W4386314624 hasConceptScore W4386314624C167135981 @default.
• W4386314624 hasConceptScore W4386314624C177713679 @default.
• W4386314624 hasConceptScore W4386314624C17923572 @default.
• W4386314624 hasConceptScore W4386314624C2776315533 @default.
• W4386314624 hasConceptScore W4386314624C2777637488 @default.
• W4386314624 hasConceptScore W4386314624C2779259085 @default.
• W4386314624 hasConceptScore W4386314624C2779343474 @default.
• W4386314624 hasConceptScore W4386314624C501593827 @default.
• W4386314624 hasConceptScore W4386314624C50382708 @default.
• W4386314624 hasConceptScore W4386314624C523546767 @default.
• W4386314624 hasConceptScore W4386314624C54355233 @default.
• W4386314624 hasConceptScore W4386314624C71924100 @default.

• next