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- W4386316627 abstract "There is data about the existence of some endocrine cells in the epithelial layer of the bile duct in humans and rats.We evaluated Ghrelin-, Insulin-, Glucagon- and Somatostatin-positive cells in peribiliary glands, mast cells, and nerve fibres.Wistar rats were used for dietary manipulation with a 15% fructose solution for 12 weeks. Tissue samples were elaborated with immunohistochemistry for Insulin, Glucagon, Ghrelin, and Somatostatin. Glucose and lipid parameters were studied.In treated animals, Ghrelin+ and Insulin+ cells in perybiliary glands (PBGs) were significantly increased. In the male fructose group there was a significant increase of the homeostasis model assessment insulin resistance (HOMA-IR).Stem/progenitor cells in extrahepatic bile tree (EHBT) could be a source of Insulin-producing cells in metabolic syndrome. Fructose treatment induces the increase of Ghrelin+ and Insulin+ cells in PBGs and the elevation of Insulin and Ghrelin plasma concentration." @default.
- W4386316627 created "2023-09-01" @default.
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- W4386316627 date "2023-08-31" @default.
- W4386316627 modified "2023-09-30" @default.
- W4386316627 title "Development of pancreatic islet cells in the extrahepatic bile ducts of rats with experimentally-induced metabolic syndrome" @default.
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- W4386316627 doi "https://doi.org/10.1080/13813455.2023.2252205" @default.
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