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- W4386317825 abstract "Cav3.2 channels belong to the T-type calcium channel (T-channel) family, i.e., low voltage-activated calcium channels, and are abundantly expressed in the nociceptors, playing a principal role in the development of pathological pain. The channel activity of Cav3.2 is suppressed by zinc under physiological conditions. We thus tested whether dietary zinc deficiency would cause Cav3.2-dependent nociceptive hypersensitivity in mice. In the mice fed with zinc deficient diet for 2 weeks, plasma zinc levels declined by more than half, and mechanical allodynia developed. The dietary zinc deficiency-induced allodynia was restored by T-channel inhibitors or by Cav3.2 gene silencing. These data demonstrate that zinc deficiency induces Cav3.2-dependent nociceptive hypersensitivity in mice, thereby suggesting that pain experienced by patients with diseases accompanied by zinc deficiency (e.g., chronic kidney disease) might involve the increased Cav3.2 activity." @default.
- W4386317825 created "2023-09-01" @default.
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- W4386317825 date "2023-09-01" @default.
- W4386317825 modified "2023-10-16" @default.
- W4386317825 title "Dietary Zinc Deficiency Induces Ca<sub>v</sub>3.2-Dependent Nociceptive Hypersensitivity in Mice" @default.
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- W4386317825 doi "https://doi.org/10.1248/bpb.b23-00270" @default.
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