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- W4386318466 abstract "African swine fever (ASF) is originally reported in East Africa as an acute hemorrhagic fever. African swine fever virus (ASFV) is a giant and complex DNA virus with icosahedral structure and encodes a variety of virulence factors to resist host innate immune response. S273R protein (pS273R), as a SUMO-1 specific cysteine protease, can affect viral packaging by cutting polymeric proteins. In this study, we found that pS273R was an important antagonistic viral factor that suppressed cGAS-STING-mediated type I interferon (IFN-I) production. A detailed analysis showed that pS273R inhibited IFN-I production by interacting with interferon regulatory factor 3 (IRF3). Subsequently, we showed that pS273R disrupted the association between TBK1 and IRF3, leading to the repressed IRF3 phosphorylation and dimerization. Deletion and point mutation analysis verified that pS273R impaired IFN-I production independent of its cysteine protease activity. These findings will help us further understand ASFV pathogenesis." @default.
- W4386318466 created "2023-09-01" @default.
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- W4386318466 date "2023-09-01" @default.
- W4386318466 modified "2023-10-03" @default.
- W4386318466 title "African swine fever virus S273R protein antagonizes type I interferon production by interfering with TBK1 and IRF3 interaction" @default.
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- W4386318466 doi "https://doi.org/10.1016/j.virs.2023.08.009" @default.
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