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- W4386323654 abstract "The formation of the human cortex in the dorsal anterior part of the central nervous system is orchestrated by several patterning centers essential to its regionalization and connectivity. The cortical layers progressively arise from radial and tangential migrations of precursor cells that are intrinsically specified to generating several populations of excitatory and inhibitory neurons. Early generated neurons of the preplate and subplate precede and govern subsequent cortical formation, while later incoming afferentsfrom thalamus and other brain regions refine its structure. While core mechanisms were described in animal models, old questions pertaining to human specificity reopened with the rise of single-cell omics applied to human, primate, and lower mammalian brains. This chapter discusses recent results in perspective with the core hypotheses of cortical development. It also highlights how organoidmodels attemptingto mimic cortical patterning in vitro have recapitulated the emergence of the cortical structure, exploring remaining interrogatives surrounding typical and altered development of the human cortex.The formation of the human cortex in the dorsal anterior part of the central nervous system is orchestrated by several patterning centers essential to its regionalization and connectivity. The cortical layers progressively arise from radial and tangential migrations of precursor cells that are intrinsically specified to generating several populations of excitatory and inhibitory neurons. Early generated neurons of the preplate and subplate precede and govern subsequent cortical formation, while later incoming afferent from thalamus and other brain regions refine its structure. While core mechanisms were described in animal models, old questions pertaining to human specificity reopened with the rise of single-cell omics applied to human, primate, and lower mammalian brains. This chapter discusses recent results in perspective with the core hypotheses of cortical development. It also highlights how organoids models attempted to mimic cortical patterning in vitro and have recapitulated the emergence of the cortical structure, exploring remaining interrogatives surrounding typical and altered development of the human cortex." @default.
- W4386323654 created "2023-09-01" @default.
- W4386323654 creator A5005905515 @default.
- W4386323654 creator A5025033341 @default.
- W4386323654 creator A5034551230 @default.
- W4386323654 date "2023-08-08" @default.
- W4386323654 modified "2023-09-27" @default.
- W4386323654 title "Early Neuronal Differentiation/patterning of the Human Pallium, Modeling by in Vitro Systems, and Disruption in Developmental Disorders" @default.
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