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- W4386324105 endingPage "e1011583" @default.
- W4386324105 startingPage "e1011583" @default.
- W4386324105 abstract "Fungal infections are rising, with over 1.5 billion cases and more than 1 million deaths recorded each year. Among these, Candida infections are frequent in at-risk populations and the rapid development of drug resistance and tolerance contributes to their clinical persistence. Few antifungal drugs are available, and their efficacy is declining due to the environmental overuse and the expansion of multidrug-resistant species. One way to prolong their utility is by applying them in combination therapy. Here, we highlight recently described azole potentiators belonging to different categories: natural, repurposed, or novel compounds. We showcase examples of molecules and discuss their identified or proposed mode of action. We also emphasise the challenges in azole potentiator development, compounded by the lack of animal testing, the overreliance on Candida albicans and Candida auris , as well as the limited understanding of compound efficacy." @default.
- W4386324105 created "2023-09-01" @default.
- W4386324105 creator A5092819272 @default.
- W4386324105 creator A5092819273 @default.
- W4386324105 date "2023-08-31" @default.
- W4386324105 modified "2023-10-03" @default.
- W4386324105 title "Azole potentiation in Candida species" @default.
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- W4386324105 doi "https://doi.org/10.1371/journal.ppat.1011583" @default.
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- W4386324105 hasPublicationYear "2023" @default.
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