Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386324369> ?p ?o ?g. }
- W4386324369 endingPage "11700" @default.
- W4386324369 startingPage "11672" @default.
- W4386324369 abstract "Because the overexpression of histone deacetylase enzymes (HDACs) has been linked to numerous diseases, including various cancers and neurodegenerative disorders, HDAC inhibitors have emerged as promising therapeutic agents. However, most HDAC inhibitors lack both subclass and isoform selectivity, which leads to potential toxicity. Unlike classical hydroxamate HDAC inhibitors, slow-binding HDAC inhibitors form tight and prolonged bonds with HDAC enzymes. This distinct mechanism of action improves both selectivity and toxicity profiles, which makes slow-binding HDAC inhibitors a promising class of therapeutic agents for various diseases. Therefore, the development of slow-binding HDAC inhibitors that can effectively target a wide range of HDAC isoforms is crucial. This Perspective provides valuable insights into the potential and progress of slow-binding HDAC inhibitors as promising drug candidates for the treatment of various diseases." @default.
- W4386324369 created "2023-09-01" @default.
- W4386324369 creator A5010758406 @default.
- W4386324369 creator A5044997693 @default.
- W4386324369 creator A5052878190 @default.
- W4386324369 date "2023-08-31" @default.
- W4386324369 modified "2023-10-15" @default.
- W4386324369 title "Evolution of Slow-Binding Inhibitors Targeting Histone Deacetylase Isoforms" @default.
- W4386324369 cites W1501954618 @default.
- W4386324369 cites W1587498640 @default.
- W4386324369 cites W1967434207 @default.
- W4386324369 cites W1967764418 @default.
- W4386324369 cites W1968620174 @default.
- W4386324369 cites W1970717269 @default.
- W4386324369 cites W1970782187 @default.
- W4386324369 cites W1972149587 @default.
- W4386324369 cites W1973685222 @default.
- W4386324369 cites W1978614608 @default.
- W4386324369 cites W1980654946 @default.
- W4386324369 cites W1980744726 @default.
- W4386324369 cites W1980941826 @default.
- W4386324369 cites W1991660464 @default.
- W4386324369 cites W1992137412 @default.
- W4386324369 cites W1993251792 @default.
- W4386324369 cites W1999928597 @default.
- W4386324369 cites W2001223686 @default.
- W4386324369 cites W2006932016 @default.
- W4386324369 cites W2007504470 @default.
- W4386324369 cites W2015074014 @default.
- W4386324369 cites W2015645056 @default.
- W4386324369 cites W2016408686 @default.
- W4386324369 cites W2019378882 @default.
- W4386324369 cites W2021060564 @default.
- W4386324369 cites W2027789746 @default.
- W4386324369 cites W2028679671 @default.
- W4386324369 cites W2029689327 @default.
- W4386324369 cites W2030718808 @default.
- W4386324369 cites W2034856420 @default.
- W4386324369 cites W2045856275 @default.
- W4386324369 cites W2046345187 @default.
- W4386324369 cites W2046392396 @default.
- W4386324369 cites W2059914085 @default.
- W4386324369 cites W2062740397 @default.
- W4386324369 cites W2071254988 @default.
- W4386324369 cites W2074370114 @default.
- W4386324369 cites W2078366144 @default.
- W4386324369 cites W2081302124 @default.
- W4386324369 cites W2084849455 @default.
- W4386324369 cites W2094034152 @default.
- W4386324369 cites W2095026025 @default.
- W4386324369 cites W2097295490 @default.
- W4386324369 cites W2101127235 @default.
- W4386324369 cites W2103579962 @default.
- W4386324369 cites W2103908660 @default.
- W4386324369 cites W2104186316 @default.
- W4386324369 cites W2107733280 @default.
- W4386324369 cites W2108017291 @default.
- W4386324369 cites W2110192861 @default.
- W4386324369 cites W2124258829 @default.
- W4386324369 cites W2125446149 @default.
- W4386324369 cites W2129651104 @default.
- W4386324369 cites W2131321938 @default.
- W4386324369 cites W2135830745 @default.
- W4386324369 cites W2139842115 @default.
- W4386324369 cites W2142233318 @default.
- W4386324369 cites W2142275018 @default.
- W4386324369 cites W2147601959 @default.
- W4386324369 cites W2148160168 @default.
- W4386324369 cites W2151089955 @default.
- W4386324369 cites W2158155007 @default.
- W4386324369 cites W2163978483 @default.
- W4386324369 cites W2207535250 @default.
- W4386324369 cites W2213075460 @default.
- W4386324369 cites W2254560754 @default.
- W4386324369 cites W2285137452 @default.
- W4386324369 cites W2313290694 @default.
- W4386324369 cites W2315176744 @default.
- W4386324369 cites W2320936212 @default.
- W4386324369 cites W2322853954 @default.
- W4386324369 cites W2331081594 @default.
- W4386324369 cites W2399229449 @default.
- W4386324369 cites W2404368222 @default.
- W4386324369 cites W2467200112 @default.
- W4386324369 cites W2473556979 @default.
- W4386324369 cites W2514358001 @default.
- W4386324369 cites W2534197624 @default.
- W4386324369 cites W2559084827 @default.
- W4386324369 cites W2591627715 @default.
- W4386324369 cites W2591958823 @default.
- W4386324369 cites W2603495945 @default.
- W4386324369 cites W2611369644 @default.
- W4386324369 cites W2734750982 @default.
- W4386324369 cites W2750986446 @default.
- W4386324369 cites W2766615847 @default.
- W4386324369 cites W2766922695 @default.
- W4386324369 cites W2790982990 @default.
- W4386324369 cites W2792072457 @default.
- W4386324369 cites W2810056186 @default.