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• W4386325567 abstract "Epilepsy is a chronic brain disease and, considering the amount of people affected of all ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure medications (ASMs) have been released since 1993, yet despite substantial advancements in our understanding of the molecular mechanisms behind epileptogenesis, over one-third of patients continue to be resistant to available therapies. This is partially explained by the fact that the majority of existing medicines only address seizure suppression rather than underlying processes. Understanding the origin of this neurological illness requires conducting human neurological and genetic studies. However, the limitation of sample sizes, ethical concerns, and the requirement for appropriate controls (many patients have already had anti-epileptic medication exposure) in human clinical trials underscore the requirement for supplemental models. So far, mammalian models of epilepsy have helped to shed light on the underlying causes of the condition, but the high costs related to breeding of the animals, low throughput, and regulatory restrictions on their research limit their usefulness in drug screening. Here, we present an overview of the state of art in epilepsy modeling describing gold standard animal models used up to date and review the possible alternatives for this research field. Our focus will be mainly on ex vivo, in vitro, and in vivo larval zebrafish models contributing to the 3R in epilepsy modeling and drug screening. We provide a description of pharmacological and genetic methods currently available but also on the possibilities offered by the continued development in gene editing methodologies, especially CRISPR/Cas9-based, for high-throughput disease modeling and anti-epileptic drugs testing." @default.
• W4386325567 created "2023-09-01" @default.
• W4386325567 creator A5000019477 @default.
• W4386325567 creator A5008705938 @default.
• W4386325567 creator A5038115432 @default.
• W4386325567 creator A5053893926 @default.
• W4386325567 creator A5079282290 @default.
• W4386325567 date "2023-08-31" @default.
• W4386325567 modified "2023-10-06" @default.
• W4386325567 title "Toward the use of novel alternative methods in epilepsy modeling and drug discovery" @default.
• W4386325567 cites W1112818150 @default.
• W4386325567 cites W1517058635 @default.
• W4386325567 cites W1591899392 @default.
• W4386325567 cites W1777628149 @default.
• W4386325567 cites W1856414226 @default.
• W4386325567 cites W1875008998 @default.
• W4386325567 cites W1964618788 @default.
• W4386325567 cites W1965703970 @default.
• W4386325567 cites W1975004590 @default.
• W4386325567 cites W1976206458 @default.
• W4386325567 cites W1979386915 @default.
• W4386325567 cites W1979767919 @default.
• W4386325567 cites W1980043169 @default.
• W4386325567 cites W1981307673 @default.
• W4386325567 cites W1981348833 @default.
• W4386325567 cites W1984701456 @default.
• W4386325567 cites W1999756778 @default.
• W4386325567 cites W2003896813 @default.
• W4386325567 cites W2004017387 @default.
• W4386325567 cites W2007248014 @default.
• W4386325567 cites W2008411490 @default.
• W4386325567 cites W2009964743 @default.
• W4386325567 cites W2013917514 @default.
• W4386325567 cites W2014115747 @default.
• W4386325567 cites W2015812851 @default.
• W4386325567 cites W2016870566 @default.
• W4386325567 cites W2017398416 @default.
• W4386325567 cites W2018286352 @default.
• W4386325567 cites W2018467317 @default.
• W4386325567 cites W2019884656 @default.
• W4386325567 cites W2021845665 @default.
• W4386325567 cites W2022316962 @default.
• W4386325567 cites W2025963445 @default.
• W4386325567 cites W2028520740 @default.
• W4386325567 cites W2029179381 @default.
• W4386325567 cites W2032621549 @default.
• W4386325567 cites W2034175439 @default.
• W4386325567 cites W2041949931 @default.
• W4386325567 cites W2042069759 @default.
• W4386325567 cites W2050659319 @default.
• W4386325567 cites W2053554987 @default.
• W4386325567 cites W2055002688 @default.
• W4386325567 cites W2060969086 @default.
• W4386325567 cites W2061473666 @default.
• W4386325567 cites W2062895901 @default.
• W4386325567 cites W2069010410 @default.
• W4386325567 cites W2071010015 @default.
• W4386325567 cites W2076781762 @default.
• W4386325567 cites W2077079412 @default.
• W4386325567 cites W2079054696 @default.
• W4386325567 cites W2079505152 @default.
• W4386325567 cites W2087669937 @default.
• W4386325567 cites W2090143998 @default.
• W4386325567 cites W2100283245 @default.
• W4386325567 cites W2103756619 @default.
• W4386325567 cites W2105352818 @default.
• W4386325567 cites W2105423985 @default.
• W4386325567 cites W2106479312 @default.
• W4386325567 cites W2109458697 @default.
• W4386325567 cites W2118564947 @default.
• W4386325567 cites W2121262376 @default.
• W4386325567 cites W2122265766 @default.
• W4386325567 cites W2136827837 @default.
• W4386325567 cites W2136963255 @default.
• W4386325567 cites W2146077311 @default.
• W4386325567 cites W2146867319 @default.
• W4386325567 cites W2149498611 @default.
• W4386325567 cites W2154363372 @default.
• W4386325567 cites W2155633484 @default.
• W4386325567 cites W2159898375 @default.
• W4386325567 cites W2162587549 @default.
• W4386325567 cites W2162904965 @default.
• W4386325567 cites W2168250872 @default.
• W4386325567 cites W2173417336 @default.
• W4386325567 cites W2178210969 @default.
• W4386325567 cites W2227079180 @default.
• W4386325567 cites W2231439883 @default.
• W4386325567 cites W2277219084 @default.
• W4386325567 cites W2277463350 @default.
• W4386325567 cites W2343277111 @default.
• W4386325567 cites W2409064028 @default.
• W4386325567 cites W2476038790 @default.
• W4386325567 cites W2486138415 @default.
• W4386325567 cites W2524916709 @default.
• W4386325567 cites W2532188391 @default.
• W4386325567 cites W2565787913 @default.
• W4386325567 cites W2568121822 @default.
• W4386325567 cites W2592509339 @default.
• W4386325567 cites W2593873339 @default.
• W4386325567 cites W2594644573 @default.

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