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- W4386325629 abstract "Pneumonia is an infection associated with substantial morbidity and mortality [1]. The etiology of pneumonia is often difficult to identify in hospitalized patients, but important to ascertain in order to enhance antibiotic stewardship [2, 3]. There is growing interest in the use of PCR-based diagnostic platforms to improve the diagnosis and treatment of pneumonia in the intensive care unit (ICU). A PCR-based test that facilitates the prompt identification of a pathogen may speed initiation of appropriate antibiotic therapy. Conversely, a negative PCR-based test that predicts a negative qualitative culture may facilitate rapid discontinuation of unnecessary broad-spectrum antibiotics [4, 5]. An area of uncertainty is how clinicians should view discordance between these two testing modalities, specifically cases with a positive PCR-based test and a negative qualitative culture. Examining the cellular characteristics of culture-negative, PCR-positive BALs may support or refute the presence of true bacterial infection. For example, an alveolar neutrophil percentage less than 50% has a negative predictive value of greater than 90% for bacterial pneumonia [6]. The goal of this study was to describe the characteristics of culture-negative, PCR-positive bronchoalveolar lavage (BAL) samples collected from critically ill patients with suspected pneumonia. Footnotes This manuscript has recently been accepted for publication in the ERJ Open Research . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJOR online. Please open or download the PDF to view this article. Conflict of interests: The authors declare no conflicts of interest." @default.
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- W4386325629 date "2023-08-31" @default.
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- W4386325629 title "Clinical Significance of Culture-Negative, PCR-Positive Bronchoalveolar Lavage Results in Severe Pneumonia" @default.
- W4386325629 doi "https://doi.org/10.1183/23120541.00343-2023" @default.
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