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• W4386325811 abstract "Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two adult-onset neurodegenerative diseases that are part of a common disease spectrum due to clinical, genetic, and pathological overlap. A prominent genetic factor contributing to both diseases is a hexanucleotide repeat expansion in a non-coding region of the C9orf72 gene. This mutation in C9orf72 leads to nuclear depletion and cytoplasmic aggregation of Tar DNA-RNA binding protein 43 (TDP-43). TDP-43 pathology is characteristic of the majority of ALS cases, irrespective of disease causation, and is present in ~50% of FTD cases. Defects in nucleocytoplasmic transport involving the nuclear pore complex, the Ran-GTPase cycle, and nuclear transport factors have been linked with the mislocalization of TDP-43. Here, we will explore and discuss the implications of these system abnormalities of nucleocytoplasmic transport in C9orf72-ALS/FTD, as well as in other forms of familial and sporadic ALS." @default.
• W4386325811 created "2023-09-01" @default.
• W4386325811 creator A5006202510 @default.
• W4386325811 creator A5058720562 @default.
• W4386325811 date "2023-08-31" @default.
• W4386325811 modified "2023-09-27" @default.
• W4386325811 title "Unraveling the impact of disrupted nucleocytoplasmic transport systems in C9orf72-associated ALS" @default.
• W4386325811 cites W1012257715 @default.
• W4386325811 cites W1137678651 @default.
• W4386325811 cites W1604716392 @default.
• W4386325811 cites W1646693466 @default.
• W4386325811 cites W1673222863 @default.
• W4386325811 cites W1796096082 @default.
• W4386325811 cites W1797572428 @default.
• W4386325811 cites W1806909159 @default.
• W4386325811 cites W1893585873 @default.
• W4386325811 cites W1970283678 @default.
• W4386325811 cites W1974448552 @default.
• W4386325811 cites W1974583546 @default.
• W4386325811 cites W1974884489 @default.
• W4386325811 cites W1978306592 @default.
• W4386325811 cites W1982119579 @default.
• W4386325811 cites W1986413768 @default.
• W4386325811 cites W1987301163 @default.
• W4386325811 cites W2014977510 @default.
• W4386325811 cites W2016010006 @default.
• W4386325811 cites W2026117939 @default.
• W4386325811 cites W2027056415 @default.
• W4386325811 cites W2036947100 @default.
• W4386325811 cites W2040029052 @default.
• W4386325811 cites W2046344492 @default.
• W4386325811 cites W2053216848 @default.
• W4386325811 cites W2059291367 @default.
• W4386325811 cites W2059697036 @default.
• W4386325811 cites W2062834772 @default.
• W4386325811 cites W2065219073 @default.
• W4386325811 cites W2073073462 @default.
• W4386325811 cites W2073707753 @default.
• W4386325811 cites W2074577396 @default.
• W4386325811 cites W2075186362 @default.
• W4386325811 cites W2080010961 @default.
• W4386325811 cites W2082602037 @default.
• W4386325811 cites W2091241169 @default.
• W4386325811 cites W2091874767 @default.
• W4386325811 cites W2093405744 @default.
• W4386325811 cites W2096578658 @default.
• W4386325811 cites W2103851941 @default.
• W4386325811 cites W2105987719 @default.
• W4386325811 cites W2108575147 @default.
• W4386325811 cites W2110068937 @default.
• W4386325811 cites W2111939527 @default.
• W4386325811 cites W2114872355 @default.
• W4386325811 cites W2116040140 @default.
• W4386325811 cites W2119679922 @default.
• W4386325811 cites W2126481945 @default.
• W4386325811 cites W2126844487 @default.
• W4386325811 cites W2127899638 @default.
• W4386325811 cites W2137039075 @default.
• W4386325811 cites W2140912731 @default.
• W4386325811 cites W2150523249 @default.
• W4386325811 cites W2154945114 @default.
• W4386325811 cites W2157108110 @default.
• W4386325811 cites W2163436690 @default.
• W4386325811 cites W2219462594 @default.
• W4386325811 cites W2219728590 @default.
• W4386325811 cites W222561556 @default.
• W4386325811 cites W2237013109 @default.
• W4386325811 cites W2300752218 @default.
• W4386325811 cites W2308742329 @default.
• W4386325811 cites W2308972158 @default.
• W4386325811 cites W2309375248 @default.
• W4386325811 cites W2366926581 @default.
• W4386325811 cites W2464250025 @default.
• W4386325811 cites W2530167760 @default.
• W4386325811 cites W2533664860 @default.
• W4386325811 cites W2534922319 @default.
• W4386325811 cites W2564004082 @default.
• W4386325811 cites W2564335181 @default.
• W4386325811 cites W2566586486 @default.
• W4386325811 cites W2569387537 @default.
• W4386325811 cites W2592379452 @default.
• W4386325811 cites W2595869676 @default.
• W4386325811 cites W2600718316 @default.
• W4386325811 cites W2603457927 @default.
• W4386325811 cites W2604650781 @default.
• W4386325811 cites W2605283453 @default.
• W4386325811 cites W2606009055 @default.
• W4386325811 cites W2611497617 @default.
• W4386325811 cites W2615294801 @default.
• W4386325811 cites W2623500277 @default.
• W4386325811 cites W2625323391 @default.
• W4386325811 cites W2734727424 @default.
• W4386325811 cites W2762922722 @default.
• W4386325811 cites W2775468657 @default.
• W4386325811 cites W2779851534 @default.
• W4386325811 cites W2782203058 @default.
• W4386325811 cites W2789717891 @default.
• W4386325811 cites W2793413213 @default.
• W4386325811 cites W2796205057 @default.
• W4386325811 cites W2801266591 @default.

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