Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386327116> ?p ?o ?g. }
- W4386327116 abstract "Chondrosarcomas and osteosarcomas are malignant bone tumors with a poor prognosis when unresectable or metastasized. Moreover, radiotherapy and chemotherapy could be ineffective. MiRNAs represent an alternative therapeutic approach. Based on high-throughput functional screening, we identified four miRNAs with a potential antiproliferative effect on SW1353 chondrosarcoma cells. Individual functional validations were then performed in SW1353 cells, as well as in three osteosarcoma cell lines. The antiproliferative and cytotoxic effects of miRNAs were evaluated in comparison with a positive control, miR-342-5p. The cytotoxic effect of four selected miRNAs was not confirmed on SW1353 cells, but we unambiguously revealed that miR-4270 had a potent cytotoxic effect on HOS and MG-63 osteosarcoma cell lines, but not on SaOS-2 cell line. Furthermore, like miR-342-5p, miR-4270 induced apoptosis in these two cell lines. In addition, we provided the first report of Bcl-xL as a direct target of miR-4270. MiR-4270 also decreased the expression of the anti-apoptotic protein Mcl-1, and increased the expression of the pro-apoptotic protein Bak. Our findings demonstrated that miR-4270 has tumor suppressive activity in osteosarcoma cells, particularly through Bcl-xL downregulation." @default.
- W4386327116 created "2023-09-01" @default.
- W4386327116 creator A5002548426 @default.
- W4386327116 creator A5004489016 @default.
- W4386327116 creator A5005939072 @default.
- W4386327116 creator A5007433897 @default.
- W4386327116 creator A5049291969 @default.
- W4386327116 creator A5050680277 @default.
- W4386327116 creator A5058425515 @default.
- W4386327116 creator A5058668061 @default.
- W4386327116 creator A5073480088 @default.
- W4386327116 creator A5082381834 @default.
- W4386327116 creator A5088552577 @default.
- W4386327116 date "2023-08-31" @default.
- W4386327116 modified "2023-10-18" @default.
- W4386327116 title "MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells" @default.
- W4386327116 cites W1503902681 @default.
- W4386327116 cites W1672380741 @default.
- W4386327116 cites W1824333186 @default.
- W4386327116 cites W1955477988 @default.
- W4386327116 cites W1969686625 @default.
- W4386327116 cites W1980088710 @default.
- W4386327116 cites W1980860406 @default.
- W4386327116 cites W1988325237 @default.
- W4386327116 cites W2000173637 @default.
- W4386327116 cites W2008710706 @default.
- W4386327116 cites W2009727781 @default.
- W4386327116 cites W2018237098 @default.
- W4386327116 cites W2020920713 @default.
- W4386327116 cites W2025584944 @default.
- W4386327116 cites W2047512035 @default.
- W4386327116 cites W2051452745 @default.
- W4386327116 cites W2063879050 @default.
- W4386327116 cites W2066547576 @default.
- W4386327116 cites W2094428504 @default.
- W4386327116 cites W2097509670 @default.
- W4386327116 cites W2099383709 @default.
- W4386327116 cites W2100936581 @default.
- W4386327116 cites W2110022678 @default.
- W4386327116 cites W2131259026 @default.
- W4386327116 cites W2135314242 @default.
- W4386327116 cites W2150312029 @default.
- W4386327116 cites W2153248764 @default.
- W4386327116 cites W2162674813 @default.
- W4386327116 cites W2170878678 @default.
- W4386327116 cites W2396745650 @default.
- W4386327116 cites W2406722806 @default.
- W4386327116 cites W2519170380 @default.
- W4386327116 cites W2522422641 @default.
- W4386327116 cites W2531928247 @default.
- W4386327116 cites W2593608043 @default.
- W4386327116 cites W2794460569 @default.
- W4386327116 cites W2808487976 @default.
- W4386327116 cites W2886514991 @default.
- W4386327116 cites W2891363625 @default.
- W4386327116 cites W2891586518 @default.
- W4386327116 cites W2899058989 @default.
- W4386327116 cites W2943196694 @default.
- W4386327116 cites W2952464260 @default.
- W4386327116 cites W2980231783 @default.
- W4386327116 cites W2987628730 @default.
- W4386327116 cites W2990205613 @default.
- W4386327116 cites W3012354820 @default.
- W4386327116 cites W3033661141 @default.
- W4386327116 cites W3087477717 @default.
- W4386327116 cites W3165217867 @default.
- W4386327116 cites W3165569238 @default.
- W4386327116 cites W4211064852 @default.
- W4386327116 cites W4220891163 @default.
- W4386327116 cites W4244853025 @default.
- W4386327116 doi "https://doi.org/10.3389/fonc.2023.1220459" @default.
- W4386327116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37719019" @default.
- W4386327116 hasPublicationYear "2023" @default.
- W4386327116 type Work @default.
- W4386327116 citedByCount "0" @default.
- W4386327116 crossrefType "journal-article" @default.
- W4386327116 hasAuthorship W4386327116A5002548426 @default.
- W4386327116 hasAuthorship W4386327116A5004489016 @default.
- W4386327116 hasAuthorship W4386327116A5005939072 @default.
- W4386327116 hasAuthorship W4386327116A5007433897 @default.
- W4386327116 hasAuthorship W4386327116A5049291969 @default.
- W4386327116 hasAuthorship W4386327116A5050680277 @default.
- W4386327116 hasAuthorship W4386327116A5058425515 @default.
- W4386327116 hasAuthorship W4386327116A5058668061 @default.
- W4386327116 hasAuthorship W4386327116A5073480088 @default.
- W4386327116 hasAuthorship W4386327116A5082381834 @default.
- W4386327116 hasAuthorship W4386327116A5088552577 @default.
- W4386327116 hasBestOaLocation W43863271161 @default.
- W4386327116 hasConcept C104317684 @default.
- W4386327116 hasConcept C121608353 @default.
- W4386327116 hasConcept C126322002 @default.
- W4386327116 hasConcept C127561419 @default.
- W4386327116 hasConcept C142724271 @default.
- W4386327116 hasConcept C145059251 @default.
- W4386327116 hasConcept C154317977 @default.
- W4386327116 hasConcept C179185449 @default.
- W4386327116 hasConcept C190283241 @default.
- W4386327116 hasConcept C202751555 @default.
- W4386327116 hasConcept C2776302905 @default.
- W4386327116 hasConcept C2777760704 @default.