Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386327475> ?p ?o ?g. }
- W4386327475 abstract "A growing number of reports of poly(ethylene glycol) (PEG)-associated immunogenicity have prompted the development of alternative polymers for bioconjugation to assist in overcoming the poor in vivo pharmacokinetic profile of proteins. In this study, we demonstrate the development of transferrin (Tf) protein–polymer conjugates using a highly hydrophilic sulfoxide polymer (poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA)) that has recently emerged as a promising class of low-fouling polymer. A cleavable thioketal linker between the protein and polymer enabled successful protein release when the conjugates were exposed to an environment rich in reactive oxygen species. Cleavage of the polymer circumvents the loss of protein activity upon chemical modification. The Tf-PMSEA conjugate was capable of significantly improving the in vivo pharmacokinetics of the protein and consequently enabled higher tumor accumulation of Tf-PMSEA in tumor-bearing mice compared to the PEGylated counterpart. This demonstrated the potential of PMSEA to be utilized in therapeutic delivery applications as a promising alternative to PEG." @default.
- W4386327475 created "2023-09-01" @default.
- W4386327475 creator A5000851503 @default.
- W4386327475 creator A5012340901 @default.
- W4386327475 creator A5013267479 @default.
- W4386327475 creator A5020086227 @default.
- W4386327475 creator A5029621120 @default.
- W4386327475 creator A5041560817 @default.
- W4386327475 creator A5046249637 @default.
- W4386327475 creator A5054282609 @default.
- W4386327475 creator A5073108451 @default.
- W4386327475 creator A5075932959 @default.
- W4386327475 date "2023-08-31" @default.
- W4386327475 modified "2023-10-14" @default.
- W4386327475 title "Stimuli-Responsive Sulfoxide Polymer–Protein Conjugates with Improved Pharmacokinetics and Tumor Delivery" @default.
- W4386327475 cites W1490299254 @default.
- W4386327475 cites W1587071366 @default.
- W4386327475 cites W1964033920 @default.
- W4386327475 cites W1976599392 @default.
- W4386327475 cites W2002333875 @default.
- W4386327475 cites W2008564265 @default.
- W4386327475 cites W2022234371 @default.
- W4386327475 cites W2030855909 @default.
- W4386327475 cites W2042117149 @default.
- W4386327475 cites W2048808551 @default.
- W4386327475 cites W2081306620 @default.
- W4386327475 cites W2083930966 @default.
- W4386327475 cites W2084587462 @default.
- W4386327475 cites W2092998512 @default.
- W4386327475 cites W2097025940 @default.
- W4386327475 cites W2124976295 @default.
- W4386327475 cites W2255928367 @default.
- W4386327475 cites W2300363746 @default.
- W4386327475 cites W2315302880 @default.
- W4386327475 cites W2323190196 @default.
- W4386327475 cites W2329318318 @default.
- W4386327475 cites W2331712740 @default.
- W4386327475 cites W2397969975 @default.
- W4386327475 cites W2410933689 @default.
- W4386327475 cites W2418409367 @default.
- W4386327475 cites W2485740051 @default.
- W4386327475 cites W2566202925 @default.
- W4386327475 cites W2568972635 @default.
- W4386327475 cites W2570979186 @default.
- W4386327475 cites W2605252073 @default.
- W4386327475 cites W2624317658 @default.
- W4386327475 cites W2727426256 @default.
- W4386327475 cites W2740695644 @default.
- W4386327475 cites W2779719913 @default.
- W4386327475 cites W2788184323 @default.
- W4386327475 cites W2800718878 @default.
- W4386327475 cites W2807753414 @default.
- W4386327475 cites W2884281341 @default.
- W4386327475 cites W2891147226 @default.
- W4386327475 cites W2902586760 @default.
- W4386327475 cites W2904389476 @default.
- W4386327475 cites W2909762186 @default.
- W4386327475 cites W2936176039 @default.
- W4386327475 cites W2958576566 @default.
- W4386327475 cites W2967873149 @default.
- W4386327475 cites W2987102589 @default.
- W4386327475 cites W2997731207 @default.
- W4386327475 cites W3005785714 @default.
- W4386327475 cites W3011668909 @default.
- W4386327475 cites W3024458539 @default.
- W4386327475 cites W3027356782 @default.
- W4386327475 cites W3085995416 @default.
- W4386327475 cites W3096686691 @default.
- W4386327475 cites W3105982350 @default.
- W4386327475 cites W3110892275 @default.
- W4386327475 cites W3111426248 @default.
- W4386327475 cites W3116360249 @default.
- W4386327475 cites W3137873823 @default.
- W4386327475 cites W3158849527 @default.
- W4386327475 cites W3162365568 @default.
- W4386327475 cites W3163900260 @default.
- W4386327475 cites W4231641520 @default.
- W4386327475 cites W4283716507 @default.
- W4386327475 cites W4292482671 @default.
- W4386327475 cites W4292814076 @default.
- W4386327475 cites W4293581898 @default.
- W4386327475 cites W4297263727 @default.
- W4386327475 cites W763963359 @default.
- W4386327475 doi "https://doi.org/10.1021/acs.chemmater.3c01566" @default.
- W4386327475 hasPublicationYear "2023" @default.
- W4386327475 type Work @default.
- W4386327475 citedByCount "0" @default.
- W4386327475 crossrefType "journal-article" @default.
- W4386327475 hasAuthorship W4386327475A5000851503 @default.
- W4386327475 hasAuthorship W4386327475A5012340901 @default.
- W4386327475 hasAuthorship W4386327475A5013267479 @default.
- W4386327475 hasAuthorship W4386327475A5020086227 @default.
- W4386327475 hasAuthorship W4386327475A5029621120 @default.
- W4386327475 hasAuthorship W4386327475A5041560817 @default.
- W4386327475 hasAuthorship W4386327475A5046249637 @default.
- W4386327475 hasAuthorship W4386327475A5054282609 @default.
- W4386327475 hasAuthorship W4386327475A5073108451 @default.
- W4386327475 hasAuthorship W4386327475A5075932959 @default.
- W4386327475 hasConcept C10138342 @default.
- W4386327475 hasConcept C111919701 @default.