Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386327556> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W4386327556 endingPage "59" @default.
- W4386327556 startingPage "48" @default.
- W4386327556 abstract "Acceptability of antituberculosis drugs by affected caregivers and children is key to disease elimination. This is affected by many factors including drug, patients, and health institution-related factors. This study aims to assess the influence of the introduction of dispersible formulation on acceptability of antituberculosis drugs. A historical cohort design was used to assess and compare the acceptability of old loose non-dispersible and new dispersible antituberculosis drugs, using a convergent parallel mixed method of data collection. Determinants of tuberculosis drug acceptability were assessed using binary logistic regression. The findings were triangulated with results from the qualitative data. The rate of acceptability of the new dispersible formulation, 112 (88.2%) was significantly higher than the rate of acceptability of old loose non-dispersible drugs, 13 (10.5%), p<0.001. The median age of children with good acceptability, 7.0 (4.0 – 10.0) years was significantly lower than those with poor acceptability, 10.0 (8.0 – 13.0) years, p <0.001. Drug formulation was a significant predictor of acceptability; the fixed-dose dispersible drug had a higher probability of being acceptable relative to lose non-dispersible formulation, (Odd Ratio = 62.3, p <0.001, 95% CI= 25.3 – 153.3). The qualitative data showed that health education about tuberculosis has positive influences on drug acceptability. In conclusion, the formulation of drugs is a key factor in the acceptability of antituberculosis drugs. Hence, there is a need to further promote the recently introduced child-friendly antituberculosis drugs, coupled with strengthening the health education of caregivers to achieve tuberculosis elimination. Keywords: Antituberculosis, Acceptability, Fixed-Dose Combination, Dispersible, Tuberculosis." @default.
- W4386327556 created "2023-09-01" @default.
- W4386327556 creator A5013649000 @default.
- W4386327556 date "2023-08-30" @default.
- W4386327556 modified "2023-09-27" @default.
- W4386327556 title "Determinants of Antituberculosis Drug Acceptability among Children with Tuberculosis in Osun State Nigeria" @default.
- W4386327556 doi "https://doi.org/10.21522/tijar.2014.se.23.01.art005" @default.
- W4386327556 hasPublicationYear "2023" @default.
- W4386327556 type Work @default.
- W4386327556 citedByCount "0" @default.
- W4386327556 crossrefType "journal-article" @default.
- W4386327556 hasAuthorship W4386327556A5013649000 @default.
- W4386327556 hasBestOaLocation W43863275561 @default.
- W4386327556 hasConcept C126322002 @default.
- W4386327556 hasConcept C142724271 @default.
- W4386327556 hasConcept C151956035 @default.
- W4386327556 hasConcept C2780035454 @default.
- W4386327556 hasConcept C2781069245 @default.
- W4386327556 hasConcept C512399662 @default.
- W4386327556 hasConcept C71924100 @default.
- W4386327556 hasConcept C72563966 @default.
- W4386327556 hasConcept C98274493 @default.
- W4386327556 hasConceptScore W4386327556C126322002 @default.
- W4386327556 hasConceptScore W4386327556C142724271 @default.
- W4386327556 hasConceptScore W4386327556C151956035 @default.
- W4386327556 hasConceptScore W4386327556C2780035454 @default.
- W4386327556 hasConceptScore W4386327556C2781069245 @default.
- W4386327556 hasConceptScore W4386327556C512399662 @default.
- W4386327556 hasConceptScore W4386327556C71924100 @default.
- W4386327556 hasConceptScore W4386327556C72563966 @default.
- W4386327556 hasConceptScore W4386327556C98274493 @default.
- W4386327556 hasLocation W43863275561 @default.
- W4386327556 hasOpenAccess W4386327556 @default.
- W4386327556 hasPrimaryLocation W43863275561 @default.
- W4386327556 hasRelatedWork W2078287435 @default.
- W4386327556 hasRelatedWork W2315085516 @default.
- W4386327556 hasRelatedWork W2316407790 @default.
- W4386327556 hasRelatedWork W2389709268 @default.
- W4386327556 hasRelatedWork W2556023802 @default.
- W4386327556 hasRelatedWork W2603773853 @default.
- W4386327556 hasRelatedWork W2884171184 @default.
- W4386327556 hasRelatedWork W2964295425 @default.
- W4386327556 hasRelatedWork W4224935498 @default.
- W4386327556 hasRelatedWork W4378220658 @default.
- W4386327556 isParatext "false" @default.
- W4386327556 isRetracted "false" @default.
- W4386327556 workType "article" @default.