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- W4386328213 startingPage "13539" @default.
- W4386328213 abstract "The members of the cytokine interleukin 17 (IL-17) family, along with their receptors (IL-17R), are vital players in a range of inflammatory diseases and cancer. Although generally regarded as proinflammatory, the effects they exhibit on cancer progression are a double-edged sword, with both antitumor and protumor activities being discovered. There is growing evidence that the IL-17 signaling pathways have significant impacts on the tumor microenvironment (TME), immune response, and inflammation in various types of cancer, including pancreatic cancer. However, the detailed mechanistic functions of the IL-17/IL-17R families in pancreatic cancer were rarely systematically elucidated. This review considers the role of the IL-17/IL-17R families in inflammation and tumor immunity and elaborates on the mechanistic functions and correlations of these members with pathogenesis, progression, and chemoresistance in pancreatic cancer. By summarizing the advanced findings on the role of IL-17/IL17R family members and IL-17 signaling pathways at the molecular level, cellular level, and disease level in pancreatic cancer, this review provides an in-depth discussion on the potential of IL-17/IL-17R as prognostic markers and therapeutic targets in pancreatic cancer." @default.
- W4386328213 created "2023-09-01" @default.
- W4386328213 creator A5002044973 @default.
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- W4386328213 creator A5070881349 @default.
- W4386328213 creator A5076594495 @default.
- W4386328213 creator A5080381188 @default.
- W4386328213 date "2023-08-31" @default.
- W4386328213 modified "2023-09-27" @default.
- W4386328213 title "Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer" @default.
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