Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386331344> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W4386331344 abstract "Abstract There are many paths for the transmission of SarsCov2 virus. The main routes are nasal and oral and the droplets carrying the virus can also be transmitted thru ocular and skin tissues. The gastrointestinal (small intestine), nasal, ocular and skin tissues all present an acidic pH milieu and therefore any treatment with antibodies thru these routes has to have the antibodies remain active at acid pH as well as be resistant to typical protease digestion. To this end we profiled our anti-SarasCov2 receptor binding domain IgY antibodies for retention of activity at acidic and basic pHs and trypsin digestion. We find that the IgY are strongly resistant to denaturation at acid pH as well as not digested by trypsin. Our data strongly support the use of these IgY in treatment of viral transmission thru the GI, nasal, ocular and skin all tissues where the pH is acidic. We also provide an enabling platform to rapidly asses the suitability of any antibody or protein therapeutic for use at acidic pH." @default.
- W4386331344 created "2023-09-01" @default.
- W4386331344 creator A5001487384 @default.
- W4386331344 creator A5021250113 @default.
- W4386331344 creator A5035199043 @default.
- W4386331344 creator A5045044181 @default.
- W4386331344 creator A5049148479 @default.
- W4386331344 creator A5055875676 @default.
- W4386331344 creator A5063552160 @default.
- W4386331344 creator A5080349714 @default.
- W4386331344 creator A5087320369 @default.
- W4386331344 date "2023-08-30" @default.
- W4386331344 modified "2023-10-01" @default.
- W4386331344 title "Robust acidic pH and digestive enzyme stability of anti-SarsCov2 IgY antibodies: Implications for treatment of viral transmission thru gastrointestinal, ocular, nasal and skin tissues" @default.
- W4386331344 cites W3009912996 @default.
- W4386331344 cites W3014067025 @default.
- W4386331344 cites W3014703367 @default.
- W4386331344 cites W3020548113 @default.
- W4386331344 cites W3158301853 @default.
- W4386331344 doi "https://doi.org/10.1101/2023.08.29.555356" @default.
- W4386331344 hasPublicationYear "2023" @default.
- W4386331344 type Work @default.
- W4386331344 citedByCount "0" @default.
- W4386331344 crossrefType "posted-content" @default.
- W4386331344 hasAuthorship W4386331344A5001487384 @default.
- W4386331344 hasAuthorship W4386331344A5021250113 @default.
- W4386331344 hasAuthorship W4386331344A5035199043 @default.
- W4386331344 hasAuthorship W4386331344A5045044181 @default.
- W4386331344 hasAuthorship W4386331344A5049148479 @default.
- W4386331344 hasAuthorship W4386331344A5055875676 @default.
- W4386331344 hasAuthorship W4386331344A5063552160 @default.
- W4386331344 hasAuthorship W4386331344A5080349714 @default.
- W4386331344 hasAuthorship W4386331344A5087320369 @default.
- W4386331344 hasBestOaLocation W43863313441 @default.
- W4386331344 hasConcept C159047783 @default.
- W4386331344 hasConcept C159654299 @default.
- W4386331344 hasConcept C181199279 @default.
- W4386331344 hasConcept C185592680 @default.
- W4386331344 hasConcept C203014093 @default.
- W4386331344 hasConcept C2522874641 @default.
- W4386331344 hasConcept C2776714187 @default.
- W4386331344 hasConcept C2780340462 @default.
- W4386331344 hasConcept C2781357212 @default.
- W4386331344 hasConcept C43617362 @default.
- W4386331344 hasConcept C55493867 @default.
- W4386331344 hasConcept C85663871 @default.
- W4386331344 hasConcept C86803240 @default.
- W4386331344 hasConcept C89423630 @default.
- W4386331344 hasConceptScore W4386331344C159047783 @default.
- W4386331344 hasConceptScore W4386331344C159654299 @default.
- W4386331344 hasConceptScore W4386331344C181199279 @default.
- W4386331344 hasConceptScore W4386331344C185592680 @default.
- W4386331344 hasConceptScore W4386331344C203014093 @default.
- W4386331344 hasConceptScore W4386331344C2522874641 @default.
- W4386331344 hasConceptScore W4386331344C2776714187 @default.
- W4386331344 hasConceptScore W4386331344C2780340462 @default.
- W4386331344 hasConceptScore W4386331344C2781357212 @default.
- W4386331344 hasConceptScore W4386331344C43617362 @default.
- W4386331344 hasConceptScore W4386331344C55493867 @default.
- W4386331344 hasConceptScore W4386331344C85663871 @default.
- W4386331344 hasConceptScore W4386331344C86803240 @default.
- W4386331344 hasConceptScore W4386331344C89423630 @default.
- W4386331344 hasLocation W43863313441 @default.
- W4386331344 hasOpenAccess W4386331344 @default.
- W4386331344 hasPrimaryLocation W43863313441 @default.
- W4386331344 hasRelatedWork W17428494 @default.
- W4386331344 hasRelatedWork W1976369551 @default.
- W4386331344 hasRelatedWork W2022672510 @default.
- W4386331344 hasRelatedWork W2024082801 @default.
- W4386331344 hasRelatedWork W2053645250 @default.
- W4386331344 hasRelatedWork W2087291913 @default.
- W4386331344 hasRelatedWork W2139983200 @default.
- W4386331344 hasRelatedWork W2156562827 @default.
- W4386331344 hasRelatedWork W2169254632 @default.
- W4386331344 hasRelatedWork W2410036357 @default.
- W4386331344 isParatext "false" @default.
- W4386331344 isRetracted "false" @default.
- W4386331344 workType "article" @default.