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- W4386332673 abstract "Abstract Background: Staphylococcus aureus is a versatile pathogen capable of causing a wide range of infections, from minor skin infections to life-threatening invasive diseases. The pathogenicity of S. aureus is attributed to its ability to produce various virulence factors, including adhesion and biofilm-related proteins. Methods: In this study, we conducted a comprehensive network meta-analysis to assess the prevalence of adhesion and biofilm-related genes in S. aureus isolates and investigate the impact of the isolate source on their occurrence. Results: A total of 53 relevant studies were included. The highest prevalence were observed for clfB ( p -estimate = 85.4), followed by eno ( p -estimate = 81.1) and icaD ( p -estimate = 77). Conversely, bap and bbp exhibited the lowest prevalence ( p -estimate = 6.7 and 18.7, respectively). The most frequently co-studied gene pairs were icaA - icaD (30 times) and fnbA - fnbB (25 times). Based on subgroup analysis the occurrence of icaC and icaB was significantly lower in animal isolates compared to human and food. Conclusion: The study revealed varying prevalence rates of adhesion and biofilm-related genes in S. aureus isolates. Our results contribute to a better understanding of S. aureus pathogenesis and can facilitate the development of effective strategies for the prevention and treatment of S. aureus infections." @default.
- W4386332673 created "2023-09-01" @default.
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- W4386332673 date "2023-08-31" @default.
- W4386332673 modified "2023-09-27" @default.
- W4386332673 title "The prevalence and comparative analysis of adhesion and biofilm-related genes in Staphylococcus aureus isolates: A network meta-analysis" @default.
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- W4386332673 doi "https://doi.org/10.21203/rs.3.rs-3298894/v1" @default.
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