Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386334078> ?p ?o ?g. }
- W4386334078 endingPage "e002901" @default.
- W4386334078 startingPage "e002901" @default.
- W4386334078 abstract "The main goal of this study was to characterise the frequency and phenotype of B, T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in peripheral blood and the cytokine environment present in circulation in children with extended oligoarticular juvenile idiopathic arthritis (extended oligo JIA) and polyarticular JIA (poly JIA) when compared with healthy controls, children with persistent oligoarticular JIA (persistent oligo JIA) and adult JIA patients.Blood samples were collected from 105 JIA patients (children and adults) and 50 age-matched healthy individuals. The frequency and phenotype of B, Tfh and Tfr cells were evaluated by flow cytometry. Serum levels of APRIL, BAFF, IL-1β, IL-2, IL-4, IL-6, IL-10, IL-17A, IL-21, IL-22, IFN-γ, PD-1, PD-L1, sCD40L, CXCL13 and TNF were measured by multiplex bead-based immunoassay and/or ELISA in all groups included.The frequency of B, Tfh and Tfr cells was similar between JIA patients and controls. Children with extended oligo JIA and poly JIA, but not persistent oligo JIA, had significantly lower frequencies of plasmablasts, regulatory T cells and higher levels of Th17-like Tfh cells in circulation when compared with controls. Furthermore, APRIL, BAFF, IL-6 and IL-17A serum levels were significantly higher in paediatric extended oligo JIA and poly JIA patients when compared with controls. These immunological alterations were not found in adult JIA patients in comparison to controls.Our results suggest a potential role and/or activation profile of B and Th17-like Tfh cells in the pathogenesis of extended oligo JIA and poly JIA, but not persistent oligo JIA." @default.
- W4386334078 created "2023-09-01" @default.
- W4386334078 creator A5004963306 @default.
- W4386334078 creator A5008585889 @default.
- W4386334078 creator A5011952532 @default.
- W4386334078 creator A5013380769 @default.
- W4386334078 creator A5013641276 @default.
- W4386334078 creator A5020189332 @default.
- W4386334078 creator A5032818232 @default.
- W4386334078 creator A5042996330 @default.
- W4386334078 creator A5043747371 @default.
- W4386334078 creator A5048823949 @default.
- W4386334078 creator A5053875772 @default.
- W4386334078 creator A5056499755 @default.
- W4386334078 creator A5060122645 @default.
- W4386334078 creator A5065254938 @default.
- W4386334078 creator A5068073716 @default.
- W4386334078 creator A5080477692 @default.
- W4386334078 creator A5082579192 @default.
- W4386334078 creator A5083988109 @default.
- W4386334078 creator A5090992257 @default.
- W4386334078 date "2023-08-01" @default.
- W4386334078 modified "2023-10-17" @default.
- W4386334078 title "Children with extended oligoarticular and polyarticular juvenile idiopathic arthritis have alterations in B and T follicular cell subsets in peripheral blood and a cytokine profile sustaining B cell activation" @default.
- W4386334078 cites W1518008196 @default.
- W4386334078 cites W1519290346 @default.
- W4386334078 cites W1550687891 @default.
- W4386334078 cites W1786481444 @default.
- W4386334078 cites W1882900263 @default.
- W4386334078 cites W1989588757 @default.
- W4386334078 cites W1991586357 @default.
- W4386334078 cites W2001386939 @default.
- W4386334078 cites W2001775594 @default.
- W4386334078 cites W2005038925 @default.
- W4386334078 cites W2009884141 @default.
- W4386334078 cites W2010387075 @default.
- W4386334078 cites W2011686037 @default.
- W4386334078 cites W2016844693 @default.
- W4386334078 cites W2017642679 @default.
- W4386334078 cites W2018987167 @default.
- W4386334078 cites W2026800023 @default.
- W4386334078 cites W2059239383 @default.
- W4386334078 cites W2063223775 @default.
- W4386334078 cites W2068543217 @default.
- W4386334078 cites W2071855390 @default.
- W4386334078 cites W2072472457 @default.
- W4386334078 cites W2084035330 @default.
- W4386334078 cites W2099273585 @default.
- W4386334078 cites W2102617539 @default.
- W4386334078 cites W2103814445 @default.
- W4386334078 cites W2113398985 @default.
- W4386334078 cites W2116670685 @default.
- W4386334078 cites W2117384908 @default.
- W4386334078 cites W2127769616 @default.
- W4386334078 cites W2134342374 @default.
- W4386334078 cites W2134389576 @default.
- W4386334078 cites W2136550752 @default.
- W4386334078 cites W2136883177 @default.
- W4386334078 cites W2137446997 @default.
- W4386334078 cites W2139998405 @default.
- W4386334078 cites W2141520396 @default.
- W4386334078 cites W2167450052 @default.
- W4386334078 cites W2168641931 @default.
- W4386334078 cites W2169466773 @default.
- W4386334078 cites W2221264044 @default.
- W4386334078 cites W2233370876 @default.
- W4386334078 cites W2312932202 @default.
- W4386334078 cites W2338738911 @default.
- W4386334078 cites W2401435409 @default.
- W4386334078 cites W2419402732 @default.
- W4386334078 cites W2520336724 @default.
- W4386334078 cites W2521750660 @default.
- W4386334078 cites W2751607427 @default.
- W4386334078 cites W2754740078 @default.
- W4386334078 cites W2800203083 @default.
- W4386334078 cites W2811489720 @default.
- W4386334078 cites W2892128713 @default.
- W4386334078 cites W2894949060 @default.
- W4386334078 cites W2898122818 @default.
- W4386334078 cites W2911031720 @default.
- W4386334078 cites W2912087422 @default.
- W4386334078 cites W2944282301 @default.
- W4386334078 cites W2960262065 @default.
- W4386334078 cites W2981351359 @default.
- W4386334078 cites W3082976402 @default.
- W4386334078 cites W3111431100 @default.
- W4386334078 cites W3153192596 @default.
- W4386334078 cites W3176725261 @default.
- W4386334078 cites W3194961990 @default.
- W4386334078 cites W3195271982 @default.
- W4386334078 cites W3204655672 @default.
- W4386334078 cites W3215920087 @default.
- W4386334078 cites W4223547560 @default.
- W4386334078 cites W4225535724 @default.
- W4386334078 cites W4246504300 @default.
- W4386334078 cites W4255497843 @default.
- W4386334078 cites W4283803161 @default.
- W4386334078 cites W4306983474 @default.