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- W4386348335 abstract "Abstract Select life stressors having enduring physiological and behavioral consequences, in part by eliciting dramatic signaling shifts in monoamine neurotransmitters. High monoamine levels can overwhelm selective transporters like the serotonin transporter. This is when polyspecific transporters like plasma membrane monoamine transporter (PMAT, Slc29a4) are hypothesized to contribute most to monoaminergic signaling regulation. Here, we employed two distinct counterbalanced stressors – fear conditioning, and swim stress – to systematically determine how reductions in PMAT function affect heterotypic stressor responsivity. We hypothesized male heterozygotes would exhibit augmented stressor responses relative to female heterozygotes. Decreased PMAT function enhanced context fear expression, an effect unexpectedly obscured by a sham stress condition. Impairments in cued fear extinction retention and enhanced context fear expression in males were conversely unmasked by sham swim condition. Abrogated corticosterone levels in male heterozygotes that underwent swim stress after context fear conditioning did not map on to any measured behaviors. In sum, male heterozygous fear behaviors proved malleable in response to preceding stressor or sham stress exposure. Combined, these data indicate reduced male PMAT function elicits a form of stress-responsive plasticity. Future studies should assess how PMAT is differentially affected in the sexes, and identify downstream consequences of the stress-shifted corticosterone dynamics." @default.
- W4386348335 created "2023-09-02" @default.
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- W4386348335 date "2023-09-01" @default.
- W4386348335 modified "2023-09-27" @default.
- W4386348335 title "Heterotypic stressors unmask behavioral influences of PMAT deficiency" @default.
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- W4386348335 doi "https://doi.org/10.1101/2023.08.30.555632" @default.
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