Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386348712> ?p ?o ?g. }
- W4386348712 abstract "Black scurf disease, caused by Rhizoctonia solani, is a severe soil-borne and tuber-borne disease, which occurs and spreads in potato growing areas worldwide and poses a serious threat to potato production. New biofungicide is highly desirable for addressing the issue, and natural products (NPs) from Xenorhabdus spp. provide prolific resources for biofungicide development. In this study, we aim to identify antifungal NPs from Xenorhabdus spp. for the management of this disease.Out of the 22 Xenorhabdus strains investigated, Xenorhabdus budapestensis 8 (XBD8) was determined to be the most promising candidate with the measured IC50 value of its cell-free supernatant against R. solani as low as 0.19 ml l-1. The major antifungal compound in XBD8 started to be synthesized in the middle logarithmic phase and reached a stable level at stationary phase. Core gene deletion coupled with high-resolution mass spectrometry analysis determined the major antifungal NPs as fabclavine derivatives, Fcl-7 and 8, which showed broad-spectrum bioactivity against important pathogenic fungi. Impressively, the identified fabclavine derivatives effectively controlled black scurf disease in both greenhouse and field experiments, significantly improving tuber quality and increasing with marketable tuber yield from 29 300 to 35 494 kg ha-1, comparable with chemical fungicide fludioxonil.The fabclavine derivatives Fcl-7 and 8 were determined as the major antifungal NPs in XBD8, which demonstrated a bright prospect for the management of black scurf disease." @default.
- W4386348712 created "2023-09-02" @default.
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- W4386348712 date "2023-09-01" @default.
- W4386348712 modified "2023-10-15" @default.
- W4386348712 title "Identification of fabclavine derivatives, Fcl-7 and Fcl-8, from <i>Xenorhabdus budapestensis</i> as major antifungal natural products against <i>Rhizoctonia solani</i>" @default.
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- W4386348712 doi "https://doi.org/10.1093/jambio/lxad190" @default.
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