Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386348769> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4386348769 abstract "Abstract Immune checkpoint inhibitors (ICIs) have significantly altered the treatment landscape for cancer in the last decade. However, their benefits are often offset by therapy-limiting immune-related adverse events (irAEs). Acute interstitial nephritis (AIN) is the most common renal irAE, but the exact mechanisms underlying its development are poorly understood. ICI-induced immune activation against drug-derived antigens, leading to an inflammatory response within the kidney interstitium, has been postulated, evidenced by current observations of a higher incidence of ICI-associated AIN in patients receiving AIN-inducing drugs such as proton pump inhibitors (PPIs). The role of PPIs in this specific context has garnered significant attention, given their ubiquitous use and sometimes misuse. In this issue of CKJ Miao et al. summarise and synthesize the best available evidence to clarify the interactions of PPIs with ICIs in the development of AIN and other adverse kidney outcomes. The sum of evidence provided appear to implicate PPIs in the development of clinically significant short- and long-term kidney-related adverse effects in patients on immune checkpoint blockade, although causality cannot be proven. In this editorial we discuss the key practical implications of these findings and emphasize the need for further quality studies to delineate the true relationship of ICIs and PPIs in the development of AIN." @default.
- W4386348769 created "2023-09-02" @default.
- W4386348769 creator A5015498310 @default.
- W4386348769 creator A5016840459 @default.
- W4386348769 date "2023-09-01" @default.
- W4386348769 modified "2023-09-27" @default.
- W4386348769 title "Proton pump inhibitors and adverse kidney outcomes during immune checkpoint blockade: time to sound the alarm?" @default.
- W4386348769 cites W1606523019 @default.
- W4386348769 cites W1980714631 @default.
- W4386348769 cites W2029235301 @default.
- W4386348769 cites W2119907303 @default.
- W4386348769 cites W2338242614 @default.
- W4386348769 cites W2413514895 @default.
- W4386348769 cites W2781799489 @default.
- W4386348769 cites W2794675594 @default.
- W4386348769 cites W2914287567 @default.
- W4386348769 cites W2980261817 @default.
- W4386348769 cites W2984413960 @default.
- W4386348769 cites W2997561837 @default.
- W4386348769 cites W3023398858 @default.
- W4386348769 cites W3035626072 @default.
- W4386348769 cites W3049624470 @default.
- W4386348769 cites W3093148975 @default.
- W4386348769 cites W3127826897 @default.
- W4386348769 cites W3173929599 @default.
- W4386348769 cites W3180735302 @default.
- W4386348769 cites W3200082291 @default.
- W4386348769 cites W3202872245 @default.
- W4386348769 cites W4206911890 @default.
- W4386348769 cites W4212914560 @default.
- W4386348769 cites W4226419855 @default.
- W4386348769 cites W4297172879 @default.
- W4386348769 cites W4318027372 @default.
- W4386348769 cites W4378718008 @default.
- W4386348769 cites W4382790817 @default.
- W4386348769 cites W4382893775 @default.
- W4386348769 doi "https://doi.org/10.1093/ckj/sfad205" @default.
- W4386348769 hasPublicationYear "2023" @default.
- W4386348769 type Work @default.
- W4386348769 citedByCount "0" @default.
- W4386348769 crossrefType "journal-article" @default.
- W4386348769 hasAuthorship W4386348769A5015498310 @default.
- W4386348769 hasAuthorship W4386348769A5016840459 @default.
- W4386348769 hasBestOaLocation W43863487691 @default.
- W4386348769 hasConcept C121608353 @default.
- W4386348769 hasConcept C126322002 @default.
- W4386348769 hasConcept C143998085 @default.
- W4386348769 hasConcept C151730666 @default.
- W4386348769 hasConcept C170493617 @default.
- W4386348769 hasConcept C177713679 @default.
- W4386348769 hasConcept C197934379 @default.
- W4386348769 hasConcept C203014093 @default.
- W4386348769 hasConcept C2777701055 @default.
- W4386348769 hasConcept C2778468042 @default.
- W4386348769 hasConcept C2779343474 @default.
- W4386348769 hasConcept C2780472472 @default.
- W4386348769 hasConcept C2780851360 @default.
- W4386348769 hasConcept C60644358 @default.
- W4386348769 hasConcept C71924100 @default.
- W4386348769 hasConcept C86803240 @default.
- W4386348769 hasConcept C8891405 @default.
- W4386348769 hasConceptScore W4386348769C121608353 @default.
- W4386348769 hasConceptScore W4386348769C126322002 @default.
- W4386348769 hasConceptScore W4386348769C143998085 @default.
- W4386348769 hasConceptScore W4386348769C151730666 @default.
- W4386348769 hasConceptScore W4386348769C170493617 @default.
- W4386348769 hasConceptScore W4386348769C177713679 @default.
- W4386348769 hasConceptScore W4386348769C197934379 @default.
- W4386348769 hasConceptScore W4386348769C203014093 @default.
- W4386348769 hasConceptScore W4386348769C2777701055 @default.
- W4386348769 hasConceptScore W4386348769C2778468042 @default.
- W4386348769 hasConceptScore W4386348769C2779343474 @default.
- W4386348769 hasConceptScore W4386348769C2780472472 @default.
- W4386348769 hasConceptScore W4386348769C2780851360 @default.
- W4386348769 hasConceptScore W4386348769C60644358 @default.
- W4386348769 hasConceptScore W4386348769C71924100 @default.
- W4386348769 hasConceptScore W4386348769C86803240 @default.
- W4386348769 hasConceptScore W4386348769C8891405 @default.
- W4386348769 hasLocation W43863487691 @default.
- W4386348769 hasOpenAccess W4386348769 @default.
- W4386348769 hasPrimaryLocation W43863487691 @default.
- W4386348769 hasRelatedWork W2051519978 @default.
- W4386348769 hasRelatedWork W2086812899 @default.
- W4386348769 hasRelatedWork W2738819638 @default.
- W4386348769 hasRelatedWork W2783137027 @default.
- W4386348769 hasRelatedWork W2805103957 @default.
- W4386348769 hasRelatedWork W2891472322 @default.
- W4386348769 hasRelatedWork W3022645438 @default.
- W4386348769 hasRelatedWork W3028011650 @default.
- W4386348769 hasRelatedWork W4307968394 @default.
- W4386348769 hasRelatedWork W4380319181 @default.
- W4386348769 isParatext "false" @default.
- W4386348769 isRetracted "false" @default.
- W4386348769 workType "article" @default.