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- W4386350420 abstract "Background: Hepatocellular carcinoma (HCC) represents the second most common cause of cancer-related death and accounts for over 80% of primary liver cancers worldwide. Curative treatment options include surgical resection in patients with well-compensated liver function and radiofrequency ablation in small tumors. However, in 90% of patients, HCC occurs in the setting of cirrhosis where optimal management remains liver transplantation (LT) with 5-year survival rates of approximately 80%. We hypothesize that atezolizumab and bevacizumab can appropriately bridge patients with HCC beyond MC to transplantation and not increase the risk of 1-year post-transplant rejection. To test this hypothesis, patients with HCC beyond Milan Criteria (in brief, 5 – 10 cm), who are transplant-eligible will be treated with 6 months of neoadjuvant/downstaging atezolizumab plus bevacizumab while receiving standard of care transarterial chemoembolization (TACE). The proposed clinical trial will evaluate the feasibility of using a combination of the chemotherapeutic interventions atezolizumab and bevacizumab in a group of patients with HCC who have tumors beyond the Milan Criteria in order to bridge them to liver transplantation." @default.
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- W4386350420 date "2023-01-01" @default.
- W4386350420 modified "2023-10-11" @default.
- W4386350420 title "Trial in Progress: Atezolizumab and Bevacizumab Pre-liver Transplantation for Patients with Hepatocellular Carcinoma beyond Milan Criteria" @default.
- W4386350420 doi "https://doi.org/10.1016/j.hpb.2023.07.756" @default.
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