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- W4386352007 abstract "Summary Working memory is a fundamental cognitive ability, allowing us to keep information in memory for the time needed to perform a given task. A complex neural circuit fulfills these functions, among which is the anterior cingulate cortex (CG). Functionally and anatomically connected to the medial prefrontal, retrosplenial, midcingulate and hippocampus, as well as motor cortices, CG has been implicated in retrieving appropriate information when needed to select and control appropriate behavior. The role of cingulate cortex in working memory-guided behaviors remains unclear due to the lack of studies reversibly interfering with its activity during specific epochs of working memory. We used eNpHR3.0 to silence cingulate neurons while animals perform a standard delayed non-match to trajectory task, and found that silencing cingulate neurons during memory retrieval, but not encoding, significantly decreases performance. Such impairment is accompanied by significantly shorter delays in reaching a decision, consistent with hastier decision-making." @default.
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- W4386352007 date "2023-09-01" @default.
- W4386352007 modified "2023-10-16" @default.
- W4386352007 title "Optogenetic silencing of the Anterior Cingulate Cortex impairs working memory in a delayed non-match to trajectory task" @default.
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- W4386352007 doi "https://doi.org/10.1101/2023.08.30.555490" @default.
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