FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386359513> ?p ?o ?g. }

• W4386359513 endingPage "e34929" @default.
• W4386359513 startingPage "e34929" @default.
• W4386359513 abstract "This study aims to analyze the potential biomarkers using bioinformatics technology, explore the pathogenesis, and investigate potential Chinese herbal ingredients for the Clear cell renal cell carcinoma (ccRCC), which could provide theoretical basis for early diagnosis and effective treatment of ccRCC. The gene expression datasets GSE6344 and GSE53757 were obtained from the Gene Expression Omnibus database to screen differentially expressed genes (DEGs) involved in ccRCC carcinogenesis and disease progression. Enrichment analyses, protein-protein interaction networks construction, survival analysis and herbal medicines screening were performed with related software and online analysis platforms. Moreover, network pharmacology analysis has also been performed to screen potential target drugs of ccRCC and molecular docking analysis has been used to validate their effects. Total 274 common DEGs were extracted through above process, including 194 up-regulated genes and 80 down-regulated genes. The enrichment analysis revealed that DEGs were significantly focused on multiple amino acid metabolism and HIF signaling pathway. Ten hub genes, including FLT1, BDNF, LCP2, AGXT2, PLG, SLC13A3, SLC47A2, SLC22A8, SLC22A7, and SLC13A3, were screened. Survival analysis showed that FLT1, BDNF, AGXT2, PLG, SLC47A2, SLC22A8, and SLC12A3 were closely correlated with the overall survival of ccRCC, and AGXT2, SLC47A2, SLC22A8, and SLC22A7 were closely associated with DFS. The potential therapeutic herbs that have been screened were Danshen, Baiguo, Yinxing, Huangqin and Chuanshanlong. The active compounds which may be effective in ccRCC treatment were kaempferol, Scillaren A and (-)-epigallocatechin-3-gallate." @default.
• W4386359513 created "2023-09-02" @default.
• W4386359513 creator A5005896076 @default.
• W4386359513 creator A5009720772 @default.
• W4386359513 creator A5022558646 @default.
• W4386359513 creator A5024888016 @default.
• W4386359513 creator A5066869574 @default.
• W4386359513 creator A5067988307 @default.
• W4386359513 creator A5074140059 @default.
• W4386359513 creator A5076139079 @default.
• W4386359513 date "2023-09-01" @default.
• W4386359513 modified "2023-10-08" @default.
• W4386359513 title "Identification of potential biomarkers and candidate therapeutic drugs for clear cell renal cell carcinoma by bioinformatic analysis and reverse network pharmacology" @default.
• W4386359513 cites W1518909941 @default.
• W4386359513 cites W1713823936 @default.
• W4386359513 cites W1974045981 @default.
• W4386359513 cites W2022182593 @default.
• W4386359513 cites W2054206661 @default.
• W4386359513 cites W2075992165 @default.
• W4386359513 cites W2106860587 @default.
• W4386359513 cites W2125605498 @default.
• W4386359513 cites W2151525923 @default.
• W4386359513 cites W2340585084 @default.
• W4386359513 cites W2544128970 @default.
• W4386359513 cites W2726542547 @default.
• W4386359513 cites W2734874846 @default.
• W4386359513 cites W2760560019 @default.
• W4386359513 cites W2807386444 @default.
• W4386359513 cites W2810166643 @default.
• W4386359513 cites W2884170377 @default.
• W4386359513 cites W2892325025 @default.
• W4386359513 cites W2896809746 @default.
• W4386359513 cites W2900436168 @default.
• W4386359513 cites W2917524635 @default.
• W4386359513 cites W2924930352 @default.
• W4386359513 cites W2928431398 @default.
• W4386359513 cites W2929315362 @default.
• W4386359513 cites W2943909912 @default.
• W4386359513 cites W2951902079 @default.
• W4386359513 cites W2967896209 @default.
• W4386359513 cites W3030427834 @default.
• W4386359513 cites W3043428374 @default.
• W4386359513 cites W3093196589 @default.
• W4386359513 cites W3110957220 @default.
• W4386359513 cites W3113862079 @default.
• W4386359513 cites W3115827821 @default.
• W4386359513 cites W3118482236 @default.
• W4386359513 cites W3122870545 @default.
• W4386359513 cites W3123540939 @default.
• W4386359513 cites W3135289686 @default.
• W4386359513 cites W3136817075 @default.
• W4386359513 cites W3182874454 @default.
• W4386359513 cites W3194602540 @default.
• W4386359513 cites W3199362447 @default.
• W4386359513 cites W3200844743 @default.
• W4386359513 cites W4205550786 @default.
• W4386359513 cites W4212823867 @default.
• W4386359513 cites W4214568954 @default.
• W4386359513 cites W4284890056 @default.
• W4386359513 cites W4287267964 @default.
• W4386359513 cites W4311048309 @default.
• W4386359513 cites W4317749344 @default.
• W4386359513 cites W4323317718 @default.
• W4386359513 doi "https://doi.org/10.1097/md.0000000000034929" @default.
• W4386359513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37657024" @default.
• W4386359513 hasPublicationYear "2023" @default.
• W4386359513 type Work @default.
• W4386359513 citedByCount "0" @default.
• W4386359513 crossrefType "journal-article" @default.
• W4386359513 hasAuthorship W4386359513A5005896076 @default.
• W4386359513 hasAuthorship W4386359513A5009720772 @default.
• W4386359513 hasAuthorship W4386359513A5022558646 @default.
• W4386359513 hasAuthorship W4386359513A5024888016 @default.
• W4386359513 hasAuthorship W4386359513A5066869574 @default.
• W4386359513 hasAuthorship W4386359513A5067988307 @default.
• W4386359513 hasAuthorship W4386359513A5074140059 @default.
• W4386359513 hasAuthorship W4386359513A5076139079 @default.
• W4386359513 hasBestOaLocation W43863595131 @default.
• W4386359513 hasConcept C121608353 @default.
• W4386359513 hasConcept C126322002 @default.
• W4386359513 hasConcept C143998085 @default.
• W4386359513 hasConcept C2777472916 @default.
• W4386359513 hasConcept C2781278892 @default.
• W4386359513 hasConcept C502942594 @default.
• W4386359513 hasConcept C54355233 @default.
• W4386359513 hasConcept C555283112 @default.
• W4386359513 hasConcept C60644358 @default.
• W4386359513 hasConcept C62112901 @default.
• W4386359513 hasConcept C70721500 @default.
• W4386359513 hasConcept C71924100 @default.
• W4386359513 hasConcept C86803240 @default.
• W4386359513 hasConceptScore W4386359513C121608353 @default.
• W4386359513 hasConceptScore W4386359513C126322002 @default.
• W4386359513 hasConceptScore W4386359513C143998085 @default.
• W4386359513 hasConceptScore W4386359513C2777472916 @default.
• W4386359513 hasConceptScore W4386359513C2781278892 @default.
• W4386359513 hasConceptScore W4386359513C502942594 @default.
• W4386359513 hasConceptScore W4386359513C54355233 @default.

• next