Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386360123> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4386360123 abstract "Parasites generally have a negative effect on the health of their host. They represent a huge health burden, as they globally affect the health of the infested human or animal in the long term and, thus, impact agricultural and socio-economic outcomes. However, parasite-driven immune-regulatory effects have been described, with potential therapeutic relevance for autoimmune diseases. While the metabolism in both the host and parasites contributes to their defense and is the basis for nematode survival in the intestine, it has remained largely understudied due to a lack of adequate technologies. We have developed and applied NAD(P)H fluorescence lifetime imaging to explanted murine intestinal tissue during infection with the natural nematode Heligmosomoides polygyrus to study the metabolic processes in both the host and parasites in a spatially resolved manner. The exploitation of the fluorescence lifetime of the co-enzymes nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), hereafter NAD(P)H, which are preserved across species, depends on their binding status and the binding site on the enzymes catalyzing metabolic processes. Focusing on the most abundantly expressed NAD(P)H-dependent enzymes, the metabolic pathways associated with anaerobic glycolysis, oxidative phosphorylation/aerobic glycolysis, and NOX-based oxidative burst, as a major defense mechanism, were distinguished, and the metabolic crosstalk between the host and parasite during infection was characterized." @default.
- W4386360123 created "2023-09-02" @default.
- W4386360123 date "2023-09-02" @default.
- W4386360123 modified "2023-09-27" @default.
- W4386360123 title "JoVE Video Dataset" @default.
- W4386360123 doi "https://doi.org/10.3791/64982-v" @default.
- W4386360123 hasPublicationYear "2023" @default.
- W4386360123 type Work @default.
- W4386360123 citedByCount "0" @default.
- W4386360123 crossrefType "journal-article" @default.
- W4386360123 hasConcept C181199279 @default.
- W4386360123 hasConcept C192989942 @default.
- W4386360123 hasConcept C20251656 @default.
- W4386360123 hasConcept C203014093 @default.
- W4386360123 hasConcept C2776706248 @default.
- W4386360123 hasConcept C2776901170 @default.
- W4386360123 hasConcept C2777989768 @default.
- W4386360123 hasConcept C2779728014 @default.
- W4386360123 hasConcept C38485361 @default.
- W4386360123 hasConcept C515207424 @default.
- W4386360123 hasConcept C55493867 @default.
- W4386360123 hasConcept C55885012 @default.
- W4386360123 hasConcept C57600042 @default.
- W4386360123 hasConcept C75520062 @default.
- W4386360123 hasConcept C83478079 @default.
- W4386360123 hasConcept C86803240 @default.
- W4386360123 hasConcept C8891405 @default.
- W4386360123 hasConceptScore W4386360123C181199279 @default.
- W4386360123 hasConceptScore W4386360123C192989942 @default.
- W4386360123 hasConceptScore W4386360123C20251656 @default.
- W4386360123 hasConceptScore W4386360123C203014093 @default.
- W4386360123 hasConceptScore W4386360123C2776706248 @default.
- W4386360123 hasConceptScore W4386360123C2776901170 @default.
- W4386360123 hasConceptScore W4386360123C2777989768 @default.
- W4386360123 hasConceptScore W4386360123C2779728014 @default.
- W4386360123 hasConceptScore W4386360123C38485361 @default.
- W4386360123 hasConceptScore W4386360123C515207424 @default.
- W4386360123 hasConceptScore W4386360123C55493867 @default.
- W4386360123 hasConceptScore W4386360123C55885012 @default.
- W4386360123 hasConceptScore W4386360123C57600042 @default.
- W4386360123 hasConceptScore W4386360123C75520062 @default.
- W4386360123 hasConceptScore W4386360123C83478079 @default.
- W4386360123 hasConceptScore W4386360123C86803240 @default.
- W4386360123 hasConceptScore W4386360123C8891405 @default.
- W4386360123 hasLocation W43863601231 @default.
- W4386360123 hasOpenAccess W4386360123 @default.
- W4386360123 hasPrimaryLocation W43863601231 @default.
- W4386360123 hasRelatedWork W1489896303 @default.
- W4386360123 hasRelatedWork W1548965962 @default.
- W4386360123 hasRelatedWork W1585891632 @default.
- W4386360123 hasRelatedWork W1820848506 @default.
- W4386360123 hasRelatedWork W2093763987 @default.
- W4386360123 hasRelatedWork W2130880511 @default.
- W4386360123 hasRelatedWork W2137996948 @default.
- W4386360123 hasRelatedWork W2158094397 @default.
- W4386360123 hasRelatedWork W2171340535 @default.
- W4386360123 hasRelatedWork W4228997543 @default.
- W4386360123 isParatext "false" @default.
- W4386360123 isRetracted "false" @default.
- W4386360123 workType "article" @default.