FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386364550> ?p ?o ?g. }

• W4386364550 endingPage "110820" @default.
• W4386364550 startingPage "110820" @default.
• W4386364550 abstract "tRNA-derived fragments (tRFs) play crucial roles in the progression of various diseases, and widely distribute in human tissues, including blood and urine. The diagnosis of enthesitis-related arthritis (ERA) is based on the observation of clinical manifestations. Therefore, we aimed to investigate whether serum tRFs can be used as diagnostic markers for ERA.Serum was collected from children admitted to the Children's Hospital Affiliated with Nanjing Medical University between February 2022 to October 2022. The expression profiles of tRFs in the serum of ERA patients (n = 5) and healthy controls (HCs; n = 5) were investigated using small RNA high-throughput sequencing. The level and diagnostic value of tRF-21-LNK8KEP1B were evaluated by real-time quantitative PCR in serum samples from 30 ERA patients and 31 HCs. The specificity and sensitivity of tRFs were determined using receiver operating characteristic analyses. Bioinformatics analysis was performed to explore and identify the potential biological pathways induced by tRFs.Ninety-eight upregulated and 63 downregulated tRFs were identified in the serum. We selected tRF-21-LNK8KEP1B as a candidate marker using KEGG pathway enrichment and PCR validation. tRF-21-LNK8KEP1B was substantially increased in the serum of ERA patients compared with that in HCs. The area under the curve (AUC) for tRF-21-LNK8KEP1B in the ERA group was 0.7849.Collectively, we demonstrated the promising role of serum tRF-21-LNK8KEP1B -levels as a diagnostic biomarker for ERA." @default.
• W4386364550 created "2023-09-02" @default.
• W4386364550 creator A5002051632 @default.
• W4386364550 creator A5003769106 @default.
• W4386364550 creator A5018674607 @default.
• W4386364550 creator A5045941736 @default.
• W4386364550 creator A5056351079 @default.
• W4386364550 creator A5063866148 @default.
• W4386364550 creator A5066749257 @default.
• W4386364550 creator A5072462484 @default.
• W4386364550 creator A5082156574 @default.
• W4386364550 creator A5086271283 @default.
• W4386364550 date "2023-11-01" @default.
• W4386364550 modified "2023-10-18" @default.
• W4386364550 title "tRF-21-LNK8KEP1B as a potential novel diagnostic biomarker for enthesitis-related arthritis" @default.
• W4386364550 cites W1810708914 @default.
• W4386364550 cites W1832399013 @default.
• W4386364550 cites W1944804641 @default.
• W4386364550 cites W2020408643 @default.
• W4386364550 cites W2022862766 @default.
• W4386364550 cites W2056831129 @default.
• W4386364550 cites W2077878598 @default.
• W4386364550 cites W2078545407 @default.
• W4386364550 cites W2097383464 @default.
• W4386364550 cites W2106039274 @default.
• W4386364550 cites W2134389576 @default.
• W4386364550 cites W2148224382 @default.
• W4386364550 cites W2149429041 @default.
• W4386364550 cites W2201382378 @default.
• W4386364550 cites W2223836536 @default.
• W4386364550 cites W2303912045 @default.
• W4386364550 cites W2393535458 @default.
• W4386364550 cites W2461266709 @default.
• W4386364550 cites W2567737075 @default.
• W4386364550 cites W2728549768 @default.
• W4386364550 cites W2766975063 @default.
• W4386364550 cites W2769036773 @default.
• W4386364550 cites W2783917615 @default.
• W4386364550 cites W2937316677 @default.
• W4386364550 cites W2943807724 @default.
• W4386364550 cites W2945463715 @default.
• W4386364550 cites W3083205881 @default.
• W4386364550 cites W3178232475 @default.
• W4386364550 doi "https://doi.org/10.1016/j.intimp.2023.110820" @default.
• W4386364550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37660592" @default.
• W4386364550 hasPublicationYear "2023" @default.
• W4386364550 type Work @default.
• W4386364550 citedByCount "0" @default.
• W4386364550 crossrefType "journal-article" @default.
• W4386364550 hasAuthorship W4386364550A5002051632 @default.
• W4386364550 hasAuthorship W4386364550A5003769106 @default.
• W4386364550 hasAuthorship W4386364550A5018674607 @default.
• W4386364550 hasAuthorship W4386364550A5045941736 @default.
• W4386364550 hasAuthorship W4386364550A5056351079 @default.
• W4386364550 hasAuthorship W4386364550A5063866148 @default.
• W4386364550 hasAuthorship W4386364550A5066749257 @default.
• W4386364550 hasAuthorship W4386364550A5072462484 @default.
• W4386364550 hasAuthorship W4386364550A5082156574 @default.
• W4386364550 hasAuthorship W4386364550A5086271283 @default.
• W4386364550 hasBestOaLocation W43863645501 @default.
• W4386364550 hasConcept C104317684 @default.
• W4386364550 hasConcept C126322002 @default.
• W4386364550 hasConcept C143998085 @default.
• W4386364550 hasConcept C150194340 @default.
• W4386364550 hasConcept C152724338 @default.
• W4386364550 hasConcept C2777077863 @default.
• W4386364550 hasConcept C2781197716 @default.
• W4386364550 hasConcept C2987395477 @default.
• W4386364550 hasConcept C3017616150 @default.
• W4386364550 hasConcept C3020132585 @default.
• W4386364550 hasConcept C54355233 @default.
• W4386364550 hasConcept C58471807 @default.
• W4386364550 hasConcept C60644358 @default.
• W4386364550 hasConcept C71924100 @default.
• W4386364550 hasConcept C86803240 @default.
• W4386364550 hasConceptScore W4386364550C104317684 @default.
• W4386364550 hasConceptScore W4386364550C126322002 @default.
• W4386364550 hasConceptScore W4386364550C143998085 @default.
• W4386364550 hasConceptScore W4386364550C150194340 @default.
• W4386364550 hasConceptScore W4386364550C152724338 @default.
• W4386364550 hasConceptScore W4386364550C2777077863 @default.
• W4386364550 hasConceptScore W4386364550C2781197716 @default.
• W4386364550 hasConceptScore W4386364550C2987395477 @default.
• W4386364550 hasConceptScore W4386364550C3017616150 @default.
• W4386364550 hasConceptScore W4386364550C3020132585 @default.
• W4386364550 hasConceptScore W4386364550C54355233 @default.
• W4386364550 hasConceptScore W4386364550C58471807 @default.
• W4386364550 hasConceptScore W4386364550C60644358 @default.
• W4386364550 hasConceptScore W4386364550C71924100 @default.
• W4386364550 hasConceptScore W4386364550C86803240 @default.
• W4386364550 hasFunder F4320321001 @default.
• W4386364550 hasFunder F4320335777 @default.
• W4386364550 hasLocation W43863645501 @default.
• W4386364550 hasLocation W43863645502 @default.
• W4386364550 hasOpenAccess W4386364550 @default.
• W4386364550 hasPrimaryLocation W43863645501 @default.
• W4386364550 hasRelatedWork W2170357356 @default.
• W4386364550 hasRelatedWork W2278981029 @default.

• next