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- W4386367022 abstract "Calcium (Ca2+) homeostasis is essential for maintaining physiological processes in the body. Disruptions in Ca2+ signaling can lead to various pathological conditions including inflammation, fibrosis, impaired immune function, and accelerated senescence. Hypocalcemia, a common symptom in diseases such as acute respiratory distress syndrome (ARDS), cancer, septic shock, and COVID-19, can have both potential protective and detrimental effects. This article explores the multifaceted role of Ca2+ dysregulation in inflammation, fibrosis, impaired immune function, and accelerated senescence, contributing to disease severity. Targeting Ca2+ signaling pathways may provide opportunities to develop novel therapeutics for age-related diseases and combat viral infections. However, the role of Ca2+ in viral infections is complex, and evidence suggests that hypocalcemia may have a protective effect against certain viruses, while changes in Ca2+ homeostasis can influence susceptibility to viral infections. The effectiveness and safety of Ca2+ supplements in COVID-19 patients remain a subject of ongoing research and debate. Further investigations are needed to understand the intricate interplay between Ca2+ signaling and disease pathogenesis." @default.
- W4386367022 created "2023-09-02" @default.
- W4386367022 creator A5009720516 @default.
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- W4386367022 creator A5050146792 @default.
- W4386367022 creator A5052289586 @default.
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- W4386367022 creator A5079862130 @default.
- W4386367022 creator A5087810107 @default.
- W4386367022 date "2023-12-01" @default.
- W4386367022 modified "2023-09-30" @default.
- W4386367022 title "Unmasking amending roles of hypocalcemia in cancer, COVID-19, and sepsis: Engineered nanodelivery and diagnosis" @default.
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