Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386367876> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W4386367876 abstract "<div>AbstractBackground:<p>A potential association between proton-pump inhibitors (PPI) and gastric cancer remains undefined. Thus, we aimed to evaluate such association within the Stomach cancer Pooling (StoP) Project.</p>Methods:<p>Data from five case–control studies of the StoP Project were included (1,889 cases and 6,517 controls). We assessed the impact of different exposure definitions, specifically any reported use of PPIs and exposure definitions based on the duration of PPI intake. Additionally, we modeled the dose–response relationship between the cumulative duration of PPI intake and gastric cancer.</p>Results:<p>Significant associations between PPI intake and gastric cancer, both overall and in the stratified analyses, were limited to exposure definitions based on short durations of intake. The overall odds ratio (OR) for any reported PPI intake was 1.78 [95% confidence interval (CI): 0.76–4.14]. In the dose–response analysis, the ORs of gastric cancer were found to be higher for short durations of PPI intake (6 months: OR 3.26; 95% CI: 2.40–4.42; one year: OR 2.14; 95% CI: 1.69–2.70; 2 years: OR 1.50; 95% CI: 1.22–1.85; 3 years: OR 1.27; 95% CI: 1.03–1.56), with the association becoming not significant for durations longer than 3 years.</p>Conclusions:<p>Our findings suggest that the observed association between PPIs and gastric cancer might be mainly due to reverse causality.</p>Impact:<p>The results of this study suggest that PPIs are a safe therapeutic choice regarding their effect on the occurrence of gastric cancer.</p><p><i><a href=https://aacrjournals.org/cebp/article/doi/10.1158/1055-9965.EPI-23-0809 target=_blank>See related commentary by Richman and Leiman, p. 1127</a></i></p></div>" @default.
- W4386367876 created "2023-09-02" @default.
- W4386367876 creator A5022224649 @default.
- W4386367876 creator A5030983004 @default.
- W4386367876 creator A5034770211 @default.
- W4386367876 creator A5034945267 @default.
- W4386367876 creator A5035334621 @default.
- W4386367876 creator A5041592879 @default.
- W4386367876 creator A5044184914 @default.
- W4386367876 creator A5048013245 @default.
- W4386367876 creator A5055939964 @default.
- W4386367876 creator A5065004369 @default.
- W4386367876 creator A5075525738 @default.
- W4386367876 creator A5080371610 @default.
- W4386367876 creator A5084739387 @default.
- W4386367876 creator A5090934538 @default.
- W4386367876 date "2023-09-01" @default.
- W4386367876 modified "2023-09-28" @default.
- W4386367876 title "Data from Intake of Proton-Pump Inhibitors and Gastric Cancer within the Stomach Cancer Pooling (StoP) Project" @default.
- W4386367876 doi "https://doi.org/10.1158/1055-9965.c.6738478.v2" @default.
- W4386367876 hasPublicationYear "2023" @default.
- W4386367876 type Work @default.
- W4386367876 citedByCount "0" @default.
- W4386367876 crossrefType "posted-content" @default.
- W4386367876 hasAuthorship W4386367876A5022224649 @default.
- W4386367876 hasAuthorship W4386367876A5030983004 @default.
- W4386367876 hasAuthorship W4386367876A5034770211 @default.
- W4386367876 hasAuthorship W4386367876A5034945267 @default.
- W4386367876 hasAuthorship W4386367876A5035334621 @default.
- W4386367876 hasAuthorship W4386367876A5041592879 @default.
- W4386367876 hasAuthorship W4386367876A5044184914 @default.
- W4386367876 hasAuthorship W4386367876A5048013245 @default.
- W4386367876 hasAuthorship W4386367876A5055939964 @default.
- W4386367876 hasAuthorship W4386367876A5065004369 @default.
- W4386367876 hasAuthorship W4386367876A5075525738 @default.
- W4386367876 hasAuthorship W4386367876A5080371610 @default.
- W4386367876 hasAuthorship W4386367876A5084739387 @default.
- W4386367876 hasAuthorship W4386367876A5090934538 @default.
- W4386367876 hasConcept C121608353 @default.
- W4386367876 hasConcept C126322002 @default.
- W4386367876 hasConcept C156957248 @default.
- W4386367876 hasConcept C2779422922 @default.
- W4386367876 hasConcept C2779454504 @default.
- W4386367876 hasConcept C44249647 @default.
- W4386367876 hasConcept C71924100 @default.
- W4386367876 hasConcept C90924648 @default.
- W4386367876 hasConceptScore W4386367876C121608353 @default.
- W4386367876 hasConceptScore W4386367876C126322002 @default.
- W4386367876 hasConceptScore W4386367876C156957248 @default.
- W4386367876 hasConceptScore W4386367876C2779422922 @default.
- W4386367876 hasConceptScore W4386367876C2779454504 @default.
- W4386367876 hasConceptScore W4386367876C44249647 @default.
- W4386367876 hasConceptScore W4386367876C71924100 @default.
- W4386367876 hasConceptScore W4386367876C90924648 @default.
- W4386367876 hasLocation W43863678761 @default.
- W4386367876 hasOpenAccess W4386367876 @default.
- W4386367876 hasPrimaryLocation W43863678761 @default.
- W4386367876 hasRelatedWork W131310205 @default.
- W4386367876 hasRelatedWork W1973855633 @default.
- W4386367876 hasRelatedWork W1994650590 @default.
- W4386367876 hasRelatedWork W2017630982 @default.
- W4386367876 hasRelatedWork W2131983647 @default.
- W4386367876 hasRelatedWork W2317313649 @default.
- W4386367876 hasRelatedWork W2352454768 @default.
- W4386367876 hasRelatedWork W2409878917 @default.
- W4386367876 hasRelatedWork W2884448048 @default.
- W4386367876 hasRelatedWork W306576806 @default.
- W4386367876 isParatext "false" @default.
- W4386367876 isRetracted "false" @default.
- W4386367876 workType "article" @default.