Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386368601> ?p ?o ?g. }
- W4386368601 abstract "Background Little research exists on how individual risk factors for Alzheimer’s disease (AD) affect the intermediate phenotype after transcranial direct current stimulation (tDCS), despite the importance of precision medicine-based therapeutic approaches. Objective To determine how an application of sequential tDCS (2 mA/day, left dorsolateral prefrontal cortex, 10 sessions) affects changes in white matter (WM) microstructure integrity in 63 mild cognitive impairment (MCI) patients with effect modifiers such as Aβ deposition, APOE ε4 carrier status, BDNF Val66Met polymorphism status, and sex. Methods We examined individual effect modifier-by-tDCS interactions and multiple effect modifiers-by-tDCS interactions for diffusion metrics. We also evaluated the association between baseline Aβ deposition and changes in WM microstructure integrity following tDCS. Results We found that APOE ε4 carrier status and sex had a significant interaction with tDCS, resulting in increased fractional anisotropy (FA) in the right uncinate fasciculus (UF) after stimulation. Additionally, we observed multiple effect modifiers-by-tDCS interactions on WM integrity of the right UF, leading to a more pronounced increase in FA values in APOE ε4 carriers and females with Val66 homozygotes. Finally, baseline Aβ deposition was positively associated with a difference in FA of the left cingulum in the hippocampal area, which showed a positive association with the changes in the score for delayed memory. Conclusion Our study shows the differential impact of individual AD risk factors on changes in the early intermediate phenotype after sequential tDCS in MCI patients. This research emphasizes the importance of precision medicine approaches in tDCS for the prodromal stages of AD." @default.
- W4386368601 created "2023-09-02" @default.
- W4386368601 creator A5002698277 @default.
- W4386368601 creator A5011082063 @default.
- W4386368601 creator A5017715628 @default.
- W4386368601 creator A5019634339 @default.
- W4386368601 creator A5043546747 @default.
- W4386368601 creator A5066242842 @default.
- W4386368601 creator A5080654961 @default.
- W4386368601 creator A5089027476 @default.
- W4386368601 date "2023-09-01" @default.
- W4386368601 modified "2023-10-07" @default.
- W4386368601 title "Impact of transcranial direct current stimulation on white matter microstructure integrity in mild cognitive impairment patients according to effect modifiers as risk factors for Alzheimer’s disease" @default.
- W4386368601 cites W1967823816 @default.
- W4386368601 cites W1981565388 @default.
- W4386368601 cites W1981734795 @default.
- W4386368601 cites W1983801775 @default.
- W4386368601 cites W1990450213 @default.
- W4386368601 cites W1996070945 @default.
- W4386368601 cites W1998261300 @default.
- W4386368601 cites W2005984136 @default.
- W4386368601 cites W2009837079 @default.
- W4386368601 cites W2010695389 @default.
- W4386368601 cites W2026823261 @default.
- W4386368601 cites W2028436804 @default.
- W4386368601 cites W2034497459 @default.
- W4386368601 cites W2034526967 @default.
- W4386368601 cites W2035351162 @default.
- W4386368601 cites W2036388365 @default.
- W4386368601 cites W2073568238 @default.
- W4386368601 cites W2082073825 @default.
- W4386368601 cites W2084335923 @default.
- W4386368601 cites W2087237482 @default.
- W4386368601 cites W2109480636 @default.
- W4386368601 cites W2109862162 @default.
- W4386368601 cites W2115625328 @default.
- W4386368601 cites W2117136254 @default.
- W4386368601 cites W2123261378 @default.
- W4386368601 cites W2137554996 @default.
- W4386368601 cites W2139662468 @default.
- W4386368601 cites W2140947257 @default.
- W4386368601 cites W2150459735 @default.
- W4386368601 cites W2152207442 @default.
- W4386368601 cites W2156295356 @default.
- W4386368601 cites W2160187938 @default.
- W4386368601 cites W2160917765 @default.
- W4386368601 cites W2162615325 @default.
- W4386368601 cites W2165153229 @default.
- W4386368601 cites W2169287801 @default.
- W4386368601 cites W2169878253 @default.
- W4386368601 cites W2296169298 @default.
- W4386368601 cites W2598070792 @default.
- W4386368601 cites W2765779419 @default.
- W4386368601 cites W2769095960 @default.
- W4386368601 cites W2810724956 @default.
- W4386368601 cites W2834941082 @default.
- W4386368601 cites W2899859490 @default.
- W4386368601 cites W2900627486 @default.
- W4386368601 cites W2908750541 @default.
- W4386368601 cites W2913386988 @default.
- W4386368601 cites W2943103900 @default.
- W4386368601 cites W2947634966 @default.
- W4386368601 cites W2948590640 @default.
- W4386368601 cites W2973351917 @default.
- W4386368601 cites W2990113394 @default.
- W4386368601 cites W2999068431 @default.
- W4386368601 cites W3001185911 @default.
- W4386368601 cites W3010794325 @default.
- W4386368601 cites W3010899232 @default.
- W4386368601 cites W3087003597 @default.
- W4386368601 cites W3091856802 @default.
- W4386368601 cites W3093551188 @default.
- W4386368601 cites W3096808785 @default.
- W4386368601 cites W3111043509 @default.
- W4386368601 cites W3160467514 @default.
- W4386368601 cites W3169382976 @default.
- W4386368601 cites W3195404378 @default.
- W4386368601 cites W3217401378 @default.
- W4386368601 cites W4211213171 @default.
- W4386368601 cites W4214512212 @default.
- W4386368601 cites W4220892977 @default.
- W4386368601 cites W4281647961 @default.
- W4386368601 doi "https://doi.org/10.3389/fnagi.2023.1234086" @default.
- W4386368601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37744398" @default.
- W4386368601 hasPublicationYear "2023" @default.
- W4386368601 type Work @default.
- W4386368601 citedByCount "0" @default.
- W4386368601 crossrefType "journal-article" @default.
- W4386368601 hasAuthorship W4386368601A5002698277 @default.
- W4386368601 hasAuthorship W4386368601A5011082063 @default.
- W4386368601 hasAuthorship W4386368601A5017715628 @default.
- W4386368601 hasAuthorship W4386368601A5019634339 @default.
- W4386368601 hasAuthorship W4386368601A5043546747 @default.
- W4386368601 hasAuthorship W4386368601A5066242842 @default.
- W4386368601 hasAuthorship W4386368601A5080654961 @default.
- W4386368601 hasAuthorship W4386368601A5089027476 @default.
- W4386368601 hasBestOaLocation W43863686011 @default.
- W4386368601 hasConcept C126322002 @default.
- W4386368601 hasConcept C126838900 @default.
- W4386368601 hasConcept C143409427 @default.