Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386373709> ?p ?o ?g. }
- W4386373709 abstract "The rapid emergence of antimicrobial resistance (AMR) pathogens highlights the urgent need to approach this global burden with alternative strategies. Cefiderocol (Fetroja®) is a clinically-used sideromycin, that is utilized for the treatment of severe drug-resistant infections, caused by Gram-negative bacteria; there is evidence of cefiderocol-resistance occurring in bacterial strains however. To increase the efficacy and extend the life-span of sideromycins, we demonstrate strong synergisms between cefiderocol and metallodrugs (e.g., colloidal bismuth citrate (CBS)), against Pseudomonas aeruginosa and Burkholderia cepacia. Moreover, CBS enhances cefiderocol efficacy against biofilm formation, suppresses the resistance development in P. aeruginosa and resensitizes clinically isolated resistant P. aeruginosa to cefiderocol. Notably, the co-therapy of CBS and cefiderocol significantly increases the survival rate of mice and decreases bacterial loads in the lung in a murine acute pneumonia model. The observed phenomena are partially attributable to the competitive binding of Bi3+ to cefiderocol with Fe3+, leading to enhanced uptake of Bi3+ and reduced levels of Fe3+ in cells. Our studies provide insight into the antimicrobial potential of metallo-sideromycins." @default.
- W4386373709 created "2023-09-02" @default.
- W4386373709 creator A5001810307 @default.
- W4386373709 creator A5004247993 @default.
- W4386373709 creator A5019795988 @default.
- W4386373709 creator A5020865835 @default.
- W4386373709 creator A5024657812 @default.
- W4386373709 creator A5037458489 @default.
- W4386373709 creator A5044554947 @default.
- W4386373709 creator A5049339155 @default.
- W4386373709 creator A5050031129 @default.
- W4386373709 creator A5067983792 @default.
- W4386373709 date "2023-09-01" @default.
- W4386373709 modified "2023-10-18" @default.
- W4386373709 title "Metallo-sideromycin as a dual functional complex for combating antimicrobial resistance" @default.
- W4386373709 cites W1969693482 @default.
- W4386373709 cites W1970654416 @default.
- W4386373709 cites W1972122276 @default.
- W4386373709 cites W1976299200 @default.
- W4386373709 cites W1984956671 @default.
- W4386373709 cites W2001906467 @default.
- W4386373709 cites W2002865102 @default.
- W4386373709 cites W2013030147 @default.
- W4386373709 cites W2020057555 @default.
- W4386373709 cites W2065389516 @default.
- W4386373709 cites W2068609007 @default.
- W4386373709 cites W2077009977 @default.
- W4386373709 cites W2078735798 @default.
- W4386373709 cites W2086417380 @default.
- W4386373709 cites W2099143902 @default.
- W4386373709 cites W2114834217 @default.
- W4386373709 cites W2115486016 @default.
- W4386373709 cites W2120061656 @default.
- W4386373709 cites W2128053708 @default.
- W4386373709 cites W2137405283 @default.
- W4386373709 cites W2145789959 @default.
- W4386373709 cites W2149088130 @default.
- W4386373709 cites W2151399020 @default.
- W4386373709 cites W2153465432 @default.
- W4386373709 cites W2196878347 @default.
- W4386373709 cites W2300011769 @default.
- W4386373709 cites W2530661320 @default.
- W4386373709 cites W2606975737 @default.
- W4386373709 cites W2791003574 @default.
- W4386373709 cites W2804005806 @default.
- W4386373709 cites W2806849503 @default.
- W4386373709 cites W2884186750 @default.
- W4386373709 cites W2893806747 @default.
- W4386373709 cites W2912585975 @default.
- W4386373709 cites W2922696371 @default.
- W4386373709 cites W2967729395 @default.
- W4386373709 cites W2968918954 @default.
- W4386373709 cites W2985445683 @default.
- W4386373709 cites W3005921653 @default.
- W4386373709 cites W3045885462 @default.
- W4386373709 cites W3082652924 @default.
- W4386373709 cites W3096471865 @default.
- W4386373709 cites W3120169709 @default.
- W4386373709 cites W3165323590 @default.
- W4386373709 cites W3172548148 @default.
- W4386373709 cites W3199351330 @default.
- W4386373709 cites W4220717800 @default.
- W4386373709 cites W4225092358 @default.
- W4386373709 cites W4226358716 @default.
- W4386373709 cites W4281923974 @default.
- W4386373709 doi "https://doi.org/10.1038/s41467-023-40828-3" @default.
- W4386373709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37658047" @default.
- W4386373709 hasPublicationYear "2023" @default.
- W4386373709 type Work @default.
- W4386373709 citedByCount "1" @default.
- W4386373709 countsByYear W43863737092023 @default.
- W4386373709 crossrefType "journal-article" @default.
- W4386373709 hasAuthorship W4386373709A5001810307 @default.
- W4386373709 hasAuthorship W4386373709A5004247993 @default.
- W4386373709 hasAuthorship W4386373709A5019795988 @default.
- W4386373709 hasAuthorship W4386373709A5020865835 @default.
- W4386373709 hasAuthorship W4386373709A5024657812 @default.
- W4386373709 hasAuthorship W4386373709A5037458489 @default.
- W4386373709 hasAuthorship W4386373709A5044554947 @default.
- W4386373709 hasAuthorship W4386373709A5049339155 @default.
- W4386373709 hasAuthorship W4386373709A5050031129 @default.
- W4386373709 hasAuthorship W4386373709A5067983792 @default.
- W4386373709 hasBestOaLocation W43863737091 @default.
- W4386373709 hasConcept C114851261 @default.
- W4386373709 hasConcept C185592680 @default.
- W4386373709 hasConcept C2777637488 @default.
- W4386373709 hasConcept C2780855054 @default.
- W4386373709 hasConcept C4937899 @default.
- W4386373709 hasConcept C501593827 @default.
- W4386373709 hasConcept C523546767 @default.
- W4386373709 hasConcept C54355233 @default.
- W4386373709 hasConcept C58123911 @default.
- W4386373709 hasConcept C86803240 @default.
- W4386373709 hasConcept C89423630 @default.
- W4386373709 hasConcept C94665300 @default.
- W4386373709 hasConceptScore W4386373709C114851261 @default.
- W4386373709 hasConceptScore W4386373709C185592680 @default.
- W4386373709 hasConceptScore W4386373709C2777637488 @default.
- W4386373709 hasConceptScore W4386373709C2780855054 @default.
- W4386373709 hasConceptScore W4386373709C4937899 @default.