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- W4386374971 abstract "Purpose To describe the longitudinal response in patients with hepatocellular carcinoma (HCC) treated with stereotactic body radiation therapy (SBRT) and who underwent liver transplant (LT) using gadoxetate-enhanced MRI. Methods Five men (median age 61y, range 57–64y) with 6 HCCs treated with SBRT (median dose 50Gy) who subsequently underwent LT were included in this retrospective study. Patients underwent gadoxetate-enhanced MRI before and after SBRT over a period of 3–18 months. Response was assessed using RECIST1.1, mRECIST, LI-RADS and image subtraction, by 2 observers in consensus. Percentage of pathologic tumor necrosis was evaluated. Results LT was performed 278 days (IQR, 148–418d) after completion of SBRT and 48d after the last MRI. Histopathology demonstrated tumor necrosis of 48±42% (range, 10-100%). Mean tumor size at baseline and last post-treatment MRIs pre-LT were 2.6±0.8cm and 2.4±0.9cm. Enhancing tumor component size at baseline MRI and last post-treatment MRI pre-LT were 1.6±0.8cm and 0.9±1.0cm. Responses assessed at the last LRI pre-LT were: partial response (PR, n=3), stable disease (SD, n=3) using RECIST1.1; complete response (CR, n=2), partial response (PR, n=2), stable disease (SD, n=2) using mRECIST; and LR-TR viable (n=4), LR-TR non-viable (n=2) using LI-RADS. At the last MRI pre-LT, per-lesion features of arterial phase hyperenhancement (APHE, 4/6), portal venous washout (3/6) and capsule (3/6) were observed. 5/6 lesions displayed a hypointense perilesional halo on hepatobiliary phase with a mean delay of 3.1months post-SBRT. Conclusions This case-series showed decreased size, persistent APHE, and incomplete pathologic necrosis in most HCCs treated with SBRT undergoing transplant." @default.
- W4386374971 created "2023-09-02" @default.
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- W4386374971 date "2023-10-01" @default.
- W4386374971 modified "2023-10-14" @default.
- W4386374971 title "Longitudinal assessment of hepatocellular carcinoma response to stereotactic body radiation using gadoxetate-enhanced MRI: a case series" @default.
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- W4386374971 doi "https://doi.org/10.1016/j.ejrad.2023.111077" @default.
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