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- W4386378076 endingPage "1394" @default.
- W4386378076 startingPage "1394" @default.
- W4386378076 abstract "Carbapenem-resistant Pseudomonas aeruginosa (CRPA) are a global health concern. The antimicrobial resistance, virulence, and molecular typing of 57 CRPA isolated from 43 patients who attended a specific Tunisian hospital from September 2018 to July 2019 were analyzed. All but one were multidrug-resistant CRPA, and 77% were difficult-to-treat-resistant (DTR) isolates. The blaVIM-2 gene was detected in four strains (6.9%), and among the 36 blaGES-positive CRPA (62%), the blaGES-5 gene was the predominant variant (86%). Three strains co-harbored the blaVIM-2 and blaGES-45 genes, and seven CRPA carried the blaSHV-2a gene (14%). OprD alterations, including truncations by insertion sequences, were observed in 18 strains. Regarding the 46 class 1 integron-positive CRPA (81%), the blaGES-5 gene was located in integron In717, while the blaGES-29 and blaGES-45 genes were found in two new integrons (In2122 and In4879), and the blaVIM-2 gene was found in In1183 and the new integron In2142. Twenty-four PFGE patterns and thirteen sequence types (three new ones) were identified. The predominant serotype O:11 and exoU (81%) were mostly associated with ST235 and the new ST3385 clones. The seven blaSHV-2a-CRPA from different patients belonged to ST3385 and the same PFGE pattern. The blaGES-5- and blaVIM-2 + blaGES-45-positive CRPA recovered mostly from ICU patients belonged to the high-risk clone ST235. Our results highlight the alarming prevalence of blaGES-5- and ST235-CRPA, the co-existence of blaGES-45 and blaVIM-2, and their location within integrons favoring their dissemination." @default.
- W4386378076 created "2023-09-02" @default.
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- W4386378076 date "2023-08-31" @default.
- W4386378076 modified "2023-10-18" @default.
- W4386378076 title "High Prevalence of GES-5 Variant and Co-Expression of VIM-2 and GES-45 among Clinical Pseudomonas aeruginosa Strains in Tunisia" @default.
- W4386378076 cites W1562215482 @default.
- W4386378076 cites W1820365147 @default.
- W4386378076 cites W1917162549 @default.
- W4386378076 cites W1975163873 @default.
- W4386378076 cites W1993037671 @default.
- W4386378076 cites W2003760642 @default.
- W4386378076 cites W2005728391 @default.
- W4386378076 cites W2006238339 @default.
- W4386378076 cites W2024263059 @default.
- W4386378076 cites W2028892116 @default.
- W4386378076 cites W2029784655 @default.
- W4386378076 cites W2054480722 @default.
- W4386378076 cites W2054983921 @default.
- W4386378076 cites W2057886492 @default.
- W4386378076 cites W2075287054 @default.
- W4386378076 cites W2078528589 @default.
- W4386378076 cites W2092876837 @default.
- W4386378076 cites W2095971260 @default.
- W4386378076 cites W2104172130 @default.
- W4386378076 cites W2106063216 @default.
- W4386378076 cites W2106108105 @default.
- W4386378076 cites W2111003578 @default.
- W4386378076 cites W2112209788 @default.
- W4386378076 cites W2114402277 @default.
- W4386378076 cites W2118477866 @default.
- W4386378076 cites W2119209016 @default.
- W4386378076 cites W2130730733 @default.
- W4386378076 cites W2132109557 @default.
- W4386378076 cites W2132329502 @default.
- W4386378076 cites W2142343447 @default.
- W4386378076 cites W2147343535 @default.
- W4386378076 cites W2148206504 @default.
- W4386378076 cites W2149088130 @default.
- W4386378076 cites W2160693392 @default.
- W4386378076 cites W2160721910 @default.
- W4386378076 cites W2163692090 @default.
- W4386378076 cites W2167789296 @default.
- W4386378076 cites W2199039939 @default.
- W4386378076 cites W2252344741 @default.
- W4386378076 cites W2286621763 @default.
- W4386378076 cites W2303008909 @default.
- W4386378076 cites W2463151657 @default.
- W4386378076 cites W2468493870 @default.
- W4386378076 cites W2509548631 @default.
- W4386378076 cites W2516362618 @default.
- W4386378076 cites W2587924352 @default.
- W4386378076 cites W2615093071 @default.
- W4386378076 cites W2635337892 @default.
- W4386378076 cites W2737879351 @default.
- W4386378076 cites W2779019546 @default.
- W4386378076 cites W2781614376 @default.
- W4386378076 cites W2807824747 @default.
- W4386378076 cites W2827743426 @default.
- W4386378076 cites W2883234304 @default.
- W4386378076 cites W2885680427 @default.
- W4386378076 cites W2900637113 @default.
- W4386378076 cites W2901429172 @default.
- W4386378076 cites W2903381708 @default.
- W4386378076 cites W2914817087 @default.
- W4386378076 cites W2922274176 @default.
- W4386378076 cites W2939347585 @default.
- W4386378076 cites W2942692700 @default.
- W4386378076 cites W2950121840 @default.
- W4386378076 cites W2958249559 @default.
- W4386378076 cites W2965760211 @default.
- W4386378076 cites W2969439338 @default.
- W4386378076 cites W2996715401 @default.
- W4386378076 cites W3043594742 @default.
- W4386378076 cites W3092018586 @default.
- W4386378076 cites W3132586356 @default.
- W4386378076 cites W3163911537 @default.
- W4386378076 cites W4207034733 @default.
- W4386378076 cites W4214922586 @default.
- W4386378076 cites W4224266833 @default.
- W4386378076 cites W4283522546 @default.
- W4386378076 cites W4283644225 @default.
- W4386378076 cites W4286633111 @default.
- W4386378076 cites W4320725379 @default.
- W4386378076 cites W4385239773 @default.
- W4386378076 cites W71214772 @default.
- W4386378076 doi "https://doi.org/10.3390/antibiotics12091394" @default.