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• W4386385307 abstract "Diagnosing chronic pulmonary aspergillosis (CPA) is still challenging, and infection with Aspergillus spp. must be detected early. The aim of this study was to evaluate, for the first time, the usefulness of a new loop-mediated isothermal amplification (LAMP) test kit in diagnosing CPA.This cross-sectional study was performed at the National Hospital Organization Kinki-Chuo Chest Medical Center. We prospectively enrolled patients with and without CPA. The primary outcomes of this study were the sensitivity and specificity of LAMP for the diagnosis of CPA.In total, 34 patients with CPA and 21 without CPA (the control group) were enrolled between October 2019 and December 2021. Among the 34 patients with CPA, cultures were positive for CPA in 16 and negative for 18. The majority of fungi isolated in sputum were A. fumigatus in 15 specimens; Aspergillus flavus was isolated in 1) LAMP demonstrated 55.9% sensitivity (95% confidence interval [CI] 37.9-72.8) and 100.0% specificity (95% CI 77.2-100.0).LAMP is an acceptable tool for diagnosing CPA, and its application in clinical practice necessitates more studies." @default.
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• W4386385307 date "2023-09-01" @default.
• W4386385307 modified "2023-10-16" @default.
• W4386385307 title "Utility of a loop-mediated isothermal amplification detection kit to diagnose chronic pulmonary aspergillosis" @default.
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• W4386385307 doi "https://doi.org/10.1016/j.jiac.2023.08.018" @default.
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