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• W4386386412 abstract "The recognition and importance of immune cells during bone regeneration, including around bone biomaterials, has led to the development of an entire field termed osteoimmunology, which focuses on the connection and interplay between the skeletal system and immune cells. Most studies have focused on the osteogenic capacity of various types of bone biomaterials, and much less focus has been placed on immune cells despite being the first cell type in contact with implantable devices. Thus, the amount of literature generated to date on this topic makes it challenging to extract needed information. This review article serves as a guide highlighting advancements made in the field of osteoimmunology emphasizing the role of the osteoimmunomodulatory properties of biomaterials and their impact on osteoinduction. First, the various immune cell types involved in bone biomaterial integration are discussed, including the prominent role of osteal macrophages (OsteoMacs) during bone regeneration. Thereafter, key biomaterial properties, including topography, wettability, surface charge, and adsorption of cytokines, growth factors, ions, and other bioactive molecules, are discussed in terms of their impact on immune responses. These findings highlight and recognize the importance of the immune system and osteoimmunology, leading to a shift in the traditional models used to understand and evaluate biomaterials for bone regeneration." @default.
• W4386386412 created "2023-09-03" @default.
• W4386386412 creator A5014877953 @default.
• W4386386412 creator A5051037094 @default.
• W4386386412 creator A5059742427 @default.
• W4386386412 creator A5087744772 @default.
• W4386386412 date "2023-09-01" @default.
• W4386386412 modified "2023-09-28" @default.
• W4386386412 title "Osteoinduction and osteoimmunology: Emerging concepts" @default.
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