FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386387957> ?p ?o ?g. }

• W4386387957 abstract "Abstract NLRP12 can affect the progression of different diseases, including hepatocellular carcinoma. However, no report on triple-negative breast cancer (TNBC) has been found. Thus, this study aimed to explore the role of NLRP12 in TNBC. In our study, immunohistochemistry, real-time quantitative PCR (qPCR), and Western blot assays were used to evaluate NLRP12 expression in TNBC tissues and cells. Then, NLRP12 lentivirus was constructed and infected into MDA-MB-231 and MDA-MB-157 cells with or without PTD-p65-P1 treatment. Next, cells were collected for cell function detection using the following procedures: colony formation assay for proliferation, Transwell for migration and invasion, and Western blot for NF-κB and MAPK pathway-associated proteins. Finally, a xenograft mouse model was applied; the tumor volume and weight were determined, and NLRP12, p-IκBb-α, and p-IκBb-α expressions were evaluated using qPCR and Western blot. Results indicated that NLRP12 was lowly expressed in TNBC tissues and cells. The inhibition of NLRP12 could induce the proliferation, migration, and invasion of TNBC cells, which also could be reversed by inhibiting the NF-κB pathway (PTD-p65-P1). Moreover, silencing of NLRP12 could upregulate p-IκBb-α, while IκBb-α, p-ERK, ERK, p-p38, p38, p-JNK, and JNK expressions remained unchanged, thereby indicating that only the NF-κB pathway could be activated by NLRP12 silencing. Furthermore, the xenograft mouse model confirmed the abovementioned findings. Therefore, the low expression of NLRP12 promoted the proliferation, migration, and invasion in TNBC cells by activating the NF-κB pathway. This study might provide insights into TNBC therapy." @default.
• W4386387957 created "2023-09-03" @default.
• W4386387957 creator A5006558799 @default.
• W4386387957 creator A5007683979 @default.
• W4386387957 creator A5026577079 @default.
• W4386387957 creator A5030533390 @default.
• W4386387957 creator A5031607870 @default.
• W4386387957 creator A5051716075 @default.
• W4386387957 date "2023-09-02" @default.
• W4386387957 modified "2023-10-18" @default.
• W4386387957 title "Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-κB Pathway" @default.
• W4386387957 cites W1877065418 @default.
• W4386387957 cites W2032661113 @default.
• W4386387957 cites W2036222092 @default.
• W4386387957 cites W2121722333 @default.
• W4386387957 cites W2125558097 @default.
• W4386387957 cites W2547386153 @default.
• W4386387957 cites W2702951782 @default.
• W4386387957 cites W2891210194 @default.
• W4386387957 cites W2911874935 @default.
• W4386387957 cites W2913004193 @default.
• W4386387957 cites W2940025522 @default.
• W4386387957 cites W2950352882 @default.
• W4386387957 cites W2989593825 @default.
• W4386387957 cites W2990988669 @default.
• W4386387957 cites W2996063374 @default.
• W4386387957 cites W2999415173 @default.
• W4386387957 cites W3000532606 @default.
• W4386387957 cites W3006482155 @default.
• W4386387957 cites W3080129151 @default.
• W4386387957 cites W3085228744 @default.
• W4386387957 cites W3093085805 @default.
• W4386387957 cites W3157214968 @default.
• W4386387957 cites W3173809086 @default.
• W4386387957 cites W3174969245 @default.
• W4386387957 cites W3190500582 @default.
• W4386387957 cites W3210754842 @default.
• W4386387957 cites W4200478352 @default.
• W4386387957 cites W4207033714 @default.
• W4386387957 cites W4210267600 @default.
• W4386387957 cites W4283721992 @default.
• W4386387957 cites W4283770634 @default.
• W4386387957 cites W4286471480 @default.
• W4386387957 cites W4293427635 @default.
• W4386387957 cites W4294724511 @default.
• W4386387957 cites W4295758771 @default.
• W4386387957 cites W4313288038 @default.
• W4386387957 doi "https://doi.org/10.1007/s12013-023-01166-9" @default.
• W4386387957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37658975" @default.
• W4386387957 hasPublicationYear "2023" @default.
• W4386387957 type Work @default.
• W4386387957 citedByCount "0" @default.
• W4386387957 crossrefType "journal-article" @default.
• W4386387957 hasAuthorship W4386387957A5006558799 @default.
• W4386387957 hasAuthorship W4386387957A5007683979 @default.
• W4386387957 hasAuthorship W4386387957A5026577079 @default.
• W4386387957 hasAuthorship W4386387957A5030533390 @default.
• W4386387957 hasAuthorship W4386387957A5031607870 @default.
• W4386387957 hasAuthorship W4386387957A5051716075 @default.
• W4386387957 hasBestOaLocation W43863879571 @default.
• W4386387957 hasConcept C104317684 @default.
• W4386387957 hasConcept C119056186 @default.
• W4386387957 hasConcept C121608353 @default.
• W4386387957 hasConcept C127561419 @default.
• W4386387957 hasConcept C137738243 @default.
• W4386387957 hasConcept C1491633281 @default.
• W4386387957 hasConcept C153911025 @default.
• W4386387957 hasConcept C185592680 @default.
• W4386387957 hasConcept C2776415932 @default.
• W4386387957 hasConcept C2777730290 @default.
• W4386387957 hasConcept C2780110267 @default.
• W4386387957 hasConcept C502942594 @default.
• W4386387957 hasConcept C51551487 @default.
• W4386387957 hasConcept C530470458 @default.
• W4386387957 hasConcept C54355233 @default.
• W4386387957 hasConcept C55493867 @default.
• W4386387957 hasConcept C57074206 @default.
• W4386387957 hasConcept C62112901 @default.
• W4386387957 hasConcept C62478195 @default.
• W4386387957 hasConcept C85265743 @default.
• W4386387957 hasConcept C86803240 @default.
• W4386387957 hasConcept C95444343 @default.
• W4386387957 hasConceptScore W4386387957C104317684 @default.
• W4386387957 hasConceptScore W4386387957C119056186 @default.
• W4386387957 hasConceptScore W4386387957C121608353 @default.
• W4386387957 hasConceptScore W4386387957C127561419 @default.
• W4386387957 hasConceptScore W4386387957C137738243 @default.
• W4386387957 hasConceptScore W4386387957C1491633281 @default.
• W4386387957 hasConceptScore W4386387957C153911025 @default.
• W4386387957 hasConceptScore W4386387957C185592680 @default.
• W4386387957 hasConceptScore W4386387957C2776415932 @default.
• W4386387957 hasConceptScore W4386387957C2777730290 @default.
• W4386387957 hasConceptScore W4386387957C2780110267 @default.
• W4386387957 hasConceptScore W4386387957C502942594 @default.
• W4386387957 hasConceptScore W4386387957C51551487 @default.
• W4386387957 hasConceptScore W4386387957C530470458 @default.
• W4386387957 hasConceptScore W4386387957C54355233 @default.
• W4386387957 hasConceptScore W4386387957C55493867 @default.
• W4386387957 hasConceptScore W4386387957C57074206 @default.
• W4386387957 hasConceptScore W4386387957C62112901 @default.

• next