Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386390576> ?p ?o ?g. }
- W4386390576 abstract "Drug-resistant Neisseria gonorrhoeae represents a major threat to public health; without new effective antibiotics, untreatable gonococcal infections loom as a real possibility. In a previous drug-repurposing study, we reported that salicylic acid had good potency against azithromycin-resistant N. gonorrhoeae. We now report that the anti-gonococcal activity in this scaffold is easily lost by inopportune substitution, but that select substituted naphthyl analogs (3b, 3o and 3p) have superior activity to salicylic acid itself. Furthermore, these compounds retained potency against multiple ceftriaxone- and azithromycin-resistant strains, exhibited rapid bactericidal activity against N. gonorrhoeae, and showed high tolerability to mammalian cells (CC50 > 128 µg/mL). Promisingly, these compounds also show very weak growth inhibition of commensal vaginal bacteria." @default.
- W4386390576 created "2023-09-03" @default.
- W4386390576 creator A5052773700 @default.
- W4386390576 creator A5061854247 @default.
- W4386390576 creator A5062624986 @default.
- W4386390576 creator A5068814682 @default.
- W4386390576 creator A5075901581 @default.
- W4386390576 creator A5086679426 @default.
- W4386390576 date "2023-09-02" @default.
- W4386390576 modified "2023-09-28" @default.
- W4386390576 title "Substituted salicylic acid analogs offer improved potency against multidrug-resistant Neisseria gonorrhoeae and good selectivity against commensal vaginal bacteria" @default.
- W4386390576 cites W1913545318 @default.
- W4386390576 cites W1994449629 @default.
- W4386390576 cites W2021842942 @default.
- W4386390576 cites W2037232786 @default.
- W4386390576 cites W2059615143 @default.
- W4386390576 cites W2111450162 @default.
- W4386390576 cites W2123377849 @default.
- W4386390576 cites W2123386797 @default.
- W4386390576 cites W2137784223 @default.
- W4386390576 cites W2412588445 @default.
- W4386390576 cites W2474255949 @default.
- W4386390576 cites W2488728930 @default.
- W4386390576 cites W2574877673 @default.
- W4386390576 cites W2593687742 @default.
- W4386390576 cites W2613613983 @default.
- W4386390576 cites W2774673861 @default.
- W4386390576 cites W2779019546 @default.
- W4386390576 cites W2791476026 @default.
- W4386390576 cites W2793556041 @default.
- W4386390576 cites W2800757323 @default.
- W4386390576 cites W2809769714 @default.
- W4386390576 cites W2892417888 @default.
- W4386390576 cites W2978418147 @default.
- W4386390576 cites W2978968003 @default.
- W4386390576 cites W2981709337 @default.
- W4386390576 cites W3000200729 @default.
- W4386390576 cites W3013024294 @default.
- W4386390576 cites W3014161470 @default.
- W4386390576 cites W3023266079 @default.
- W4386390576 cites W3026141987 @default.
- W4386390576 cites W3047007341 @default.
- W4386390576 cites W3075820966 @default.
- W4386390576 cites W3088245433 @default.
- W4386390576 cites W3111151712 @default.
- W4386390576 cites W3112824113 @default.
- W4386390576 cites W3122048911 @default.
- W4386390576 cites W3130289473 @default.
- W4386390576 cites W3135440154 @default.
- W4386390576 cites W3137647537 @default.
- W4386390576 cites W3146078615 @default.
- W4386390576 cites W3164085725 @default.
- W4386390576 cites W3211014900 @default.
- W4386390576 cites W4200156776 @default.
- W4386390576 cites W4200422017 @default.
- W4386390576 cites W4213380636 @default.
- W4386390576 cites W4214900432 @default.
- W4386390576 cites W4224301125 @default.
- W4386390576 cites W4293780028 @default.
- W4386390576 cites W4295037525 @default.
- W4386390576 doi "https://doi.org/10.1038/s41598-023-41442-5" @default.
- W4386390576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37660222" @default.
- W4386390576 hasPublicationYear "2023" @default.
- W4386390576 type Work @default.
- W4386390576 citedByCount "0" @default.
- W4386390576 crossrefType "journal-article" @default.
- W4386390576 hasAuthorship W4386390576A5052773700 @default.
- W4386390576 hasAuthorship W4386390576A5061854247 @default.
- W4386390576 hasAuthorship W4386390576A5062624986 @default.
- W4386390576 hasAuthorship W4386390576A5068814682 @default.
- W4386390576 hasAuthorship W4386390576A5075901581 @default.
- W4386390576 hasAuthorship W4386390576A5086679426 @default.
- W4386390576 hasBestOaLocation W43863905761 @default.
- W4386390576 hasConcept C159047783 @default.
- W4386390576 hasConcept C185592680 @default.
- W4386390576 hasConcept C202751555 @default.
- W4386390576 hasConcept C2776983459 @default.
- W4386390576 hasConcept C2777954195 @default.
- W4386390576 hasConcept C2778907293 @default.
- W4386390576 hasConcept C2779166590 @default.
- W4386390576 hasConcept C2780104969 @default.
- W4386390576 hasConcept C2909760446 @default.
- W4386390576 hasConcept C3013748606 @default.
- W4386390576 hasConcept C4937899 @default.
- W4386390576 hasConcept C501593827 @default.
- W4386390576 hasConcept C523546767 @default.
- W4386390576 hasConcept C54355233 @default.
- W4386390576 hasConcept C55493867 @default.
- W4386390576 hasConcept C57992300 @default.
- W4386390576 hasConcept C86803240 @default.
- W4386390576 hasConcept C89423630 @default.
- W4386390576 hasConcept C98274493 @default.
- W4386390576 hasConceptScore W4386390576C159047783 @default.
- W4386390576 hasConceptScore W4386390576C185592680 @default.
- W4386390576 hasConceptScore W4386390576C202751555 @default.
- W4386390576 hasConceptScore W4386390576C2776983459 @default.
- W4386390576 hasConceptScore W4386390576C2777954195 @default.
- W4386390576 hasConceptScore W4386390576C2778907293 @default.
- W4386390576 hasConceptScore W4386390576C2779166590 @default.
- W4386390576 hasConceptScore W4386390576C2780104969 @default.