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- W4386391330 endingPage "136557" @default.
- W4386391330 startingPage "136557" @default.
- W4386391330 abstract "Methicillin-resistant Staphylococcus aureus (MRSA) is an important bacterial pathogen that has the capability to cause mild to life-threatening infections. It has posed a significant threat to the healthcare system across the globe since its emergence in the 1960s. Since then, it has rapidly evolved and developed resistance to various antibiotics from time to time and forced research groups to look for newer antibiotics. Currently, MRSA is resistant to the large portion of available antibiotics in clinical practice which created a global emergency to develop novel and effective antibiotics against MRSA. 1,2,3-Triazole is a diverse nucleus in the field of medicinal chemistry and bioisostere to amide, ester, carboxylic acid and other heterocyclic fragments as well as an integral part of antibacterial agents like cefatrizine and tazobactam, therefore act as an important tool for drug development targeting MRSA. This review will provide, a) Key information about the pathogenesis and drug resistance pattern of MRSA among available antibiotics. b) Rational design strategies utilized in the development of anti-MRSA agents using triazole nucleus and c) Pharmacological outcomes along with a critical discussion on structure activity relationships. This review will help various research groups across the globe in designing novel, potent and effective anti-MRSA agents by rational utilization of 1,2,3-triazole nucleus to overcome drug resistance acquired by MRSA." @default.
- W4386391330 created "2023-09-03" @default.
- W4386391330 creator A5007941660 @default.
- W4386391330 creator A5029548750 @default.
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- W4386391330 creator A5070106234 @default.
- W4386391330 creator A5078584120 @default.
- W4386391330 creator A5082759614 @default.
- W4386391330 date "2024-01-01" @default.
- W4386391330 modified "2023-09-29" @default.
- W4386391330 title "Rational utilization of 1,2,3-triazole scaffold in anti-MRSA drug development: Design strategies, Structural insights and Pharmacological outcomes" @default.
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