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• W4386391879 endingPage "103077" @default.
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• W4386391879 abstract "NOD-like receptor X1 (NLRX1) is known for its unique mitochondrial localization and plays a negative role in innate immunity. The initial characterization and function of chicken NLRX1 remain unclear. Here, chicken mitochondrial-targeted NLRX1 (chNLRX1) protein was identified. It had relatively conserved domains, a unique N-terminal X mitochondrial-targeting domain (MT) and 2 highly conserved motifs at positions 510-520 and 412-421. Furthermore, chNLRX1 had a unique 53aa N-terminus-MT consistent with its localization to mitochondria. Additionally, chNLRX1 was observed to reduce the DNA sensing adaptor stimulator of interferon genes (STING)-induced IFN-β by attenuating the STING-TANK-binding kinase 1 (TBK1) interaction, which is a requisite for the STING-TBK1-IFN-β signaling pathway. These results suggested that chNLRX1 negatively regulated type-I interferon production via STING in host innate immunity." @default.
• W4386391879 created "2023-09-03" @default.
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• W4386391879 date "2023-11-01" @default.
• W4386391879 modified "2023-10-16" @default.
• W4386391879 title "Molecular characterization of a novel mitochondrial Nod-like receptor X1 in chicken that negatively regulates IFN-ꞵ expression via STING" @default.
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• W4386391879 doi "https://doi.org/10.1016/j.psj.2023.103077" @default.
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• W4386391879 hasPublicationYear "2023" @default.
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