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- W4386393305 abstract "Background and Objectives: Kidney disease is a worldwide public health problem, with increasing incidence and prevalence, high costs, and poor outcomes. Chronic Kidney Disease involves an irreversible loss of renal function. This results in increased Blood Urea Nitrogen (BUN) levels which may lead to high concentration of salivary urea nitrogen (SUN) levels. BUN is directly related to the excretory function of the kidney. Salivary based investigation provide an attractive alternative for blood, as it is a safe, noninvasive, cost effective technique for screening, detection and monitoring of disease with good cooperation by patients. This study was undertaken to estimate and correlate urea nitrogen levels in serum and saliva of CKD patients and to evaluate the use of salivary urea nitrogen as an effective alternative biomarker to serum urea nitrogen in CKD patients. A total of 40 subjects comp Methods: rising of 20 healthy controls (Group I) and 20 cases of CKD (Group II) were selected. The selected cases were clinically diagnosed and conrmed cases of various stages of chronic kidney disease. 2ml of stimulated saliva and blood samples were collected from both the groups. Using urease/glutamate dehydrogenase method, the concentration of urea nitrogen levels in serum and saliva was evaluated. In the present study we found signicant correlation of serum urea nitrogen and salivary Results: urea nitrogen in both controls and CKD cases. Serum urea nitrogen and salivary urea nitrogen were both increased in CKD cases. Serum urea nitrogen and salivary urea nitrogen increased as CKD progressed. We therefore recommend, salivary u Conclusion: rea nitrogen as a biomarker in CKD. We also recommend the use of salivary urea nitrogen as an alternative biomarker to serum urea nitrogen in CKD. We suggest the use of salivary urea nitrogen to diagnose, stage and monitor management of CKD. Salivary urea nitrogen can also be used as a prognostic indicator in evaluating adequacy of dialysis and monitoring renal disease status." @default.
- W4386393305 created "2023-09-03" @default.
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- W4386393305 date "2023-08-15" @default.
- W4386393305 modified "2023-10-02" @default.
- W4386393305 title "COMPARATIVE EVALUATION OF UREA NITROGEN LEVEL IN SERUM AND SALIVA OF CHRONIC KIDNEY DISEASE PATIENTS" @default.
- W4386393305 doi "https://doi.org/10.36106/gjra/8105818" @default.
- W4386393305 hasPublicationYear "2023" @default.
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