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• W4386394087 abstract "Long noncoding RNA (lncRNA) IDH1 antisense RNA 1(IDH1-AS1) is involved in the progression of multiple tumors, but its role in epithelial ovarian cancer (EOC) is unknown. Therefore, we investigated the expression level of IDH1-AS1 in EOC cells and normal ovarian epithelial cells by quantitative real-time PCR (qPCR). We first evaluated the effects of IDH1-AS1 on the proliferation, migration, and invasion of EOC cells through cell counting kit-8, colony formation, EdU, transwell, wound-healing, and xenograft assays. We then explored the downstream targets of IDH1-AS1 and verified the results by dual-luciferase reporter, qPCR, rescure experiments, and Western blotting. We found that the expression level of IDH1-AS1 was lower in EOC cells than in normal ovarian epithelial cells. High IDH1-AS1 expression of EOC patients from the Gene Expression Profiling Interactive Analysis database indicated favorable prognosis, because IDH1-AS1 inhibited cells proliferation and xenograft tumor growth of EOC. It is likely that IDH1-AS1 may sponge miR-518c-5p whose overexpression promoted EOC cells proliferation. The miR-518c-5p mimic also reversed the proliferation inhibiting effect induced by IDH1-AS1 overexpression. Furthermore, we found that RNA binding motif protein 47 (RBM47) was the downstream target of miR-518c-5p, that upregulation of RBM47 inhibited EOC cells proliferation, and that RBM47 overexpressing plasmid counteracted the proliferation promoting effect caused by IDH1-AS1 knockdown. Taken together, IDH1-AS1 may suppress EOC cell proliferation and tumor growth <i>via</i> the miR-518c-5p/RBM47 axis." @default.
• W4386394087 created "2023-09-03" @default.
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• W4386394087 date "2023-01-01" @default.
• W4386394087 modified "2023-09-27" @default.
• W4386394087 title "LncRNA IDH1-AS1 sponges miR-518c-5p to suppress proliferation of epithelial ovarian cancer cell by targeting RMB47" @default.
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• W4386394087 doi "https://doi.org/10.7555/jbr.37.20230097" @default.
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