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- W4386397635 endingPage "101101" @default.
- W4386397635 startingPage "101101" @default.
- W4386397635 abstract "Androgens’ pleiotropic actions in promoting sex differences present not only a challenge to providing a comprehensive account of their function, but also an opportunity to gain insights by comparing androgenic actions across organ systems. Although often overlooked by neuroscientists, skeletal muscle is another androgen-responsive organ system which shares with the nervous system properties of electrochemical excitability, behavioral relevance, and remarkable capacity for adaptive plasticity. Here we review androgenic regulation of mitogenic plasticity in skeletal muscle with the goal of identifying areas of interest to those researching androgenic mechanisms mediating sexual differentiation of neurogenesis. We use an organizational-activational framework to relate broad areas of similarity and difference between androgen effects on mitogenesis in muscle and brain throughout the lifespan, from early organogenesis, through pubertal organization, adult activation, and aging. The focus of the review is androgenic regulation of muscle-specific stem cells (satellite cells), which share with neural stem cells essential functions in development, plasticity, and repair, albeit with distinct, muscle-specific features. Also considered are areas of paracrine and endocrine interaction between androgen action on muscle and nervous system, including mediation of neural plasticity of innervating and distal neural populations by muscle-produced trophic factors." @default.
- W4386397635 created "2023-09-03" @default.
- W4386397635 creator A5018695099 @default.
- W4386397635 creator A5087621371 @default.
- W4386397635 date "2023-10-01" @default.
- W4386397635 modified "2023-09-26" @default.
- W4386397635 title "Androgen Action on Myogenesis Throughout the Lifespan; Comparison with Neurogenesis" @default.
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