Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386400536> ?p ?o ?g. }
- W4386400536 abstract "Probiotics are the treasure of the microbiology fields. They have been widely used in the food industry, clinical treatment, and other fields. The equivocal health-promoting effects and the unknown action mechanism were the largest obstacles for further probiotic’s developed applications. In recent years, various genome editing techniques have been developed and applied to explore the mechanisms and functional modifications of probiotics. As important genome editing tools, CRISPR-Cas systems that have opened new improvements in genome editing dedicated to probiotics. The high efficiency, flexibility, and specificity are the advantages of using CRISPR-Cas systems. Here, we summarize the classification and distribution of CRISPR-Cas systems in probiotics, as well as the editing tools developed on the basis of them. Then, we discuss the genome editing of probiotics based on CRISPR-Cas systems and the applications of the engineered probiotics through CRISPR-Cas systems. Finally, we proposed a design route for CRISPR systems that related to the genetically engineered probiotics." @default.
- W4386400536 created "2023-09-04" @default.
- W4386400536 creator A5017360203 @default.
- W4386400536 creator A5034524285 @default.
- W4386400536 creator A5080816874 @default.
- W4386400536 date "2023-01-01" @default.
- W4386400536 modified "2023-10-15" @default.
- W4386400536 title "CRISPR-Cas-based engineering of probiotics" @default.
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