Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386400629> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W4386400629 endingPage "108968" @default.
- W4386400629 startingPage "108968" @default.
- W4386400629 abstract "Fungal alkylresorcinols are a class of polyketides, which are commonly synthesized by the hybridization of highly reducing polyketide synthase (hrPKS) with non-reducing polyketide synthase (nrPKS). In this study, we identified and demonstrated a new assembly model for synthesizing alkylresorcinol (1), which was accomplished by collaboration of a hrPKS (FscA) and a type III PKS (FscB). Furthermore, three post-tailoring enzymes (FscC, FscD, and FscE) act iteratively on 1 skeleton, including successive 14e− oxidation of inert carbons, di-halogenation, and di-methylation, to form highly oxidized and multi-substituted alkylresorcinols. Our work presents an unusual synthesis manner of alkylresorcinols, sheds light on the collaborative mechanism between hrPKS and type III PKS and provides three valuable enzymatic catalysts for the tailoring of alkylresorcinol family natural products in future." @default.
- W4386400629 created "2023-09-04" @default.
- W4386400629 creator A5004117781 @default.
- W4386400629 creator A5008798308 @default.
- W4386400629 creator A5023386062 @default.
- W4386400629 creator A5054001032 @default.
- W4386400629 creator A5070346418 @default.
- W4386400629 date "2023-09-01" @default.
- W4386400629 modified "2023-09-29" @default.
- W4386400629 title "Genome mining of multi-substituted alkylresorcinols from a hybrid highly reducing- and type III- polyketide pathway" @default.
- W4386400629 cites W1225486811 @default.
- W4386400629 cites W1978989082 @default.
- W4386400629 cites W1985702178 @default.
- W4386400629 cites W1989773731 @default.
- W4386400629 cites W1990763845 @default.
- W4386400629 cites W1998204858 @default.
- W4386400629 cites W2000990355 @default.
- W4386400629 cites W2005284935 @default.
- W4386400629 cites W2031290750 @default.
- W4386400629 cites W2075934694 @default.
- W4386400629 cites W2093386502 @default.
- W4386400629 cites W2113296988 @default.
- W4386400629 cites W2302507488 @default.
- W4386400629 cites W2333096653 @default.
- W4386400629 cites W2578925273 @default.
- W4386400629 cites W2626492834 @default.
- W4386400629 cites W2799944448 @default.
- W4386400629 cites W2801396520 @default.
- W4386400629 cites W2811245482 @default.
- W4386400629 cites W2901261375 @default.
- W4386400629 cites W2905340019 @default.
- W4386400629 cites W2912144750 @default.
- W4386400629 cites W2942612932 @default.
- W4386400629 cites W2971267407 @default.
- W4386400629 cites W2999955875 @default.
- W4386400629 cites W3012521310 @default.
- W4386400629 cites W3015317641 @default.
- W4386400629 cites W3048424489 @default.
- W4386400629 cites W3048480790 @default.
- W4386400629 cites W3048853891 @default.
- W4386400629 cites W3133518875 @default.
- W4386400629 cites W3134912112 @default.
- W4386400629 cites W3135143119 @default.
- W4386400629 cites W3145500112 @default.
- W4386400629 cites W3191820221 @default.
- W4386400629 cites W3193456053 @default.
- W4386400629 cites W3197671743 @default.
- W4386400629 cites W4213437856 @default.
- W4386400629 cites W4221051050 @default.
- W4386400629 cites W4280634458 @default.
- W4386400629 cites W4310433451 @default.
- W4386400629 cites W4313824501 @default.
- W4386400629 doi "https://doi.org/10.1016/j.cclet.2023.108968" @default.
- W4386400629 hasPublicationYear "2023" @default.
- W4386400629 type Work @default.
- W4386400629 citedByCount "0" @default.
- W4386400629 crossrefType "journal-article" @default.
- W4386400629 hasAuthorship W4386400629A5004117781 @default.
- W4386400629 hasAuthorship W4386400629A5008798308 @default.
- W4386400629 hasAuthorship W4386400629A5023386062 @default.
- W4386400629 hasAuthorship W4386400629A5054001032 @default.
- W4386400629 hasAuthorship W4386400629A5070346418 @default.
- W4386400629 hasConcept C181199279 @default.
- W4386400629 hasConcept C185592680 @default.
- W4386400629 hasConcept C21951064 @default.
- W4386400629 hasConcept C2777763344 @default.
- W4386400629 hasConcept C2778635478 @default.
- W4386400629 hasConcept C553450214 @default.
- W4386400629 hasConcept C55493867 @default.
- W4386400629 hasConcept C71240020 @default.
- W4386400629 hasConceptScore W4386400629C181199279 @default.
- W4386400629 hasConceptScore W4386400629C185592680 @default.
- W4386400629 hasConceptScore W4386400629C21951064 @default.
- W4386400629 hasConceptScore W4386400629C2777763344 @default.
- W4386400629 hasConceptScore W4386400629C2778635478 @default.
- W4386400629 hasConceptScore W4386400629C553450214 @default.
- W4386400629 hasConceptScore W4386400629C55493867 @default.
- W4386400629 hasConceptScore W4386400629C71240020 @default.
- W4386400629 hasLocation W43864006291 @default.
- W4386400629 hasOpenAccess W4386400629 @default.
- W4386400629 hasPrimaryLocation W43864006291 @default.
- W4386400629 hasRelatedWork W1986743634 @default.
- W4386400629 hasRelatedWork W1994361647 @default.
- W4386400629 hasRelatedWork W2025677032 @default.
- W4386400629 hasRelatedWork W2025799059 @default.
- W4386400629 hasRelatedWork W2033666439 @default.
- W4386400629 hasRelatedWork W2048422892 @default.
- W4386400629 hasRelatedWork W2080279693 @default.
- W4386400629 hasRelatedWork W2148964398 @default.
- W4386400629 hasRelatedWork W2575413608 @default.
- W4386400629 hasRelatedWork W2865428008 @default.
- W4386400629 isParatext "false" @default.
- W4386400629 isRetracted "false" @default.
- W4386400629 workType "article" @default.