FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386401322> ?p ?o ?g. }

• W4386401322 abstract "Abstract Background Barrett’s Esophagus (BE) is the only known precursor for esophageal adenocarcinoma (EAC), a highly lethal malignancy which has had increasing incidence in Western populations over the last 40 years. Recommendations are for endoscopic screening of patients with multiple risk factors for BE, however most eligible patients are not undergoing such evaluation, or failing to be referred, leading to most patients with EAC being diagnosed without an existing BE diagnosis. EsoGuard® (EG) is a commercially available biomarker test for detection of BE, and when used to analyze cells collected non-endoscopically with EsoCheck® (EC), may serve as an easily accessible and well-tolerated diagnostic tool that has been recognized by the ACG and AGA as a reasonable alternative to screening endoscopy. The aim of this study was to evaluate the clinical utility of EG as a triage test for upper endoscopy in the diagnose BE in real world use. Methods We present the first data snapshot from a multi-center, observational trial evaluating the CL inical U tility of E soGuard (CLUE) among physicians who have adopted the technology into their clinical practice. At the time of data snapshot, four centers had contributed to enrollment of 275 subjects between February 23, 2023, to July 28, 2023. Participating centers followed their own standard practices for determining whom to test with EG on cells collected with EC and subsequent management of the patient following results. Demographics, risk factors, test results, and subsequent management decisions were collected and analyzed. The clinical utility of the technology was evaluated based on the impact of the EG test results on the ordering physician’s decision to refer or not refer a patient for further endoscopic evaluation. Results Among 275 subjects contributing data for analysis, the average age was 61.9 years, and there was a similar distribution among males and females. Eighty-nine-point seven percent (89.7%) reported a history of chronic GERD, and 73.8% had GERD plus an additional 3 BE risk factors (i.e., ACG screening cohort). 232 subjects had EG results documented at the time of data analysis, among which 229 also had a physician decision on endoscopy referral. Total EG positivity rate was 29.3% (68/232) and 65.5% (152/232) were negative; the positive agreement between positive EG results and referral for endoscopy was 100%. The negative agreement between a negative EG result and non-referral for endoscopy was 99.3%. The overall concordance between EG result and endoscopy referral was 98.8%. This did not substantially differ between the ACG screening cohort compared to others. Conclusions Data from the first snapshot of the CLUE study demonstrates physicians ordering EC/EG in the commercial setting are reliably utilizing EG results as a triage tool to guide referrals for endoscopic evaluation of BE. Physicians always refer EG(+) individual for additional endoscopic evaluation, whereas EG(-) subjects are consistently being spared an invasive test." @default.
• W4386401322 created "2023-09-04" @default.
• W4386401322 creator A5002596362 @default.
• W4386401322 creator A5008549410 @default.
• W4386401322 creator A5038116093 @default.
• W4386401322 creator A5052521306 @default.
• W4386401322 creator A5054941430 @default.
• W4386401322 creator A5071048397 @default.
• W4386401322 creator A5071713713 @default.
• W4386401322 creator A5079602288 @default.
• W4386401322 date "2023-09-02" @default.
• W4386401322 modified "2023-10-16" @default.
• W4386401322 title "Clinical Utility Study of EsoGuard on Samples Collected with EsoCheck as a Triage Test for Endoscopy to Identify Barrett's Esophagus - Interim Data of the First 275 Subjects" @default.
• W4386401322 cites W1987652016 @default.
• W4386401322 cites W2023770280 @default.
• W4386401322 cites W2036788069 @default.
• W4386401322 cites W2038303258 @default.
• W4386401322 cites W2103246760 @default.
• W4386401322 cites W2120450267 @default.
• W4386401322 cites W2158690779 @default.
• W4386401322 cites W2193107892 @default.
• W4386401322 cites W2570454533 @default.
• W4386401322 cites W2589530974 @default.
• W4386401322 cites W2784162035 @default.
• W4386401322 cites W2790768124 @default.
• W4386401322 cites W2793897631 @default.
• W4386401322 cites W2799734651 @default.
• W4386401322 cites W2947234218 @default.
• W4386401322 cites W2969502958 @default.
• W4386401322 cites W3031309936 @default.
• W4386401322 cites W3046326116 @default.
• W4386401322 cites W3131574742 @default.
• W4386401322 cites W3158008244 @default.
• W4386401322 cites W3216394740 @default.
• W4386401322 cites W4210756392 @default.
• W4386401322 cites W4220663768 @default.
• W4386401322 cites W4283790380 @default.
• W4386401322 cites W4304196358 @default.
• W4386401322 doi "https://doi.org/10.1101/2023.08.31.23294916" @default.
• W4386401322 hasPublicationYear "2023" @default.
• W4386401322 type Work @default.
• W4386401322 citedByCount "0" @default.
• W4386401322 crossrefType "posted-content" @default.
• W4386401322 hasAuthorship W4386401322A5002596362 @default.
• W4386401322 hasAuthorship W4386401322A5008549410 @default.
• W4386401322 hasAuthorship W4386401322A5038116093 @default.
• W4386401322 hasAuthorship W4386401322A5052521306 @default.
• W4386401322 hasAuthorship W4386401322A5054941430 @default.
• W4386401322 hasAuthorship W4386401322A5071048397 @default.
• W4386401322 hasAuthorship W4386401322A5071713713 @default.
• W4386401322 hasAuthorship W4386401322A5079602288 @default.
• W4386401322 hasBestOaLocation W43864013221 @default.
• W4386401322 hasConcept C120665830 @default.
• W4386401322 hasConcept C121332964 @default.
• W4386401322 hasConcept C121608353 @default.
• W4386401322 hasConcept C126322002 @default.
• W4386401322 hasConcept C144024400 @default.
• W4386401322 hasConcept C149923435 @default.
• W4386401322 hasConcept C166957645 @default.
• W4386401322 hasConcept C194828623 @default.
• W4386401322 hasConcept C23131810 @default.
• W4386401322 hasConcept C2776957806 @default.
• W4386401322 hasConcept C2777120189 @default.
• W4386401322 hasConcept C2778451229 @default.
• W4386401322 hasConcept C2778589982 @default.
• W4386401322 hasConcept C2779399171 @default.
• W4386401322 hasConcept C2780084366 @default.
• W4386401322 hasConcept C2781182431 @default.
• W4386401322 hasConcept C2992824209 @default.
• W4386401322 hasConcept C535046627 @default.
• W4386401322 hasConcept C61434518 @default.
• W4386401322 hasConcept C61511704 @default.
• W4386401322 hasConcept C71924100 @default.
• W4386401322 hasConcept C95457728 @default.
• W4386401322 hasConceptScore W4386401322C120665830 @default.
• W4386401322 hasConceptScore W4386401322C121332964 @default.
• W4386401322 hasConceptScore W4386401322C121608353 @default.
• W4386401322 hasConceptScore W4386401322C126322002 @default.
• W4386401322 hasConceptScore W4386401322C144024400 @default.
• W4386401322 hasConceptScore W4386401322C149923435 @default.
• W4386401322 hasConceptScore W4386401322C166957645 @default.
• W4386401322 hasConceptScore W4386401322C194828623 @default.
• W4386401322 hasConceptScore W4386401322C23131810 @default.
• W4386401322 hasConceptScore W4386401322C2776957806 @default.
• W4386401322 hasConceptScore W4386401322C2777120189 @default.
• W4386401322 hasConceptScore W4386401322C2778451229 @default.
• W4386401322 hasConceptScore W4386401322C2778589982 @default.
• W4386401322 hasConceptScore W4386401322C2779399171 @default.
• W4386401322 hasConceptScore W4386401322C2780084366 @default.
• W4386401322 hasConceptScore W4386401322C2781182431 @default.
• W4386401322 hasConceptScore W4386401322C2992824209 @default.
• W4386401322 hasConceptScore W4386401322C535046627 @default.
• W4386401322 hasConceptScore W4386401322C61434518 @default.
• W4386401322 hasConceptScore W4386401322C61511704 @default.
• W4386401322 hasConceptScore W4386401322C71924100 @default.
• W4386401322 hasConceptScore W4386401322C95457728 @default.
• W4386401322 hasLocation W43864013221 @default.
• W4386401322 hasOpenAccess W4386401322 @default.
• W4386401322 hasPrimaryLocation W43864013221 @default.
• W4386401322 hasRelatedWork W2081905278 @default.

• next