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- W4386407542 abstract "Juvenile-onset fibromyalgia (JFM) is a paradigmatic chronic pain condition for which the underlying neurobiological substrates are poorly understood. This study examined for the first time data-driven resting-state functional connectivity (rsFC) alterations in 37 female adolescents with JFM compared with 43 healthy female adolescents, and identified associations with bodily pain.Whole-brain voxel-wise rsFC alterations were assessed using the intrinsic connectivity contrast, a measure of node centrality at each voxel, and seed-based analyses for interpretability. We studied the relationship between rsFC alterations in somatosensory systems and location and extension of bodily pain.Adolescents with JFM had voxel-wise rsFC reductions in the paracentral lobule (PCL)/primary somatosensory cortex (S1) (T=4.89, pFWE<.001) and left midcingulate cortex (T=4.67, pFWE=.043). Post-hoc analyses revealed reduced rsFC spanning major cortical sensory hubs (T's>4.4, pFWE's<.030). Cortico-cortical rsFC reductions within PCL/S1 in JFM occurred in locations innervated by bodily areas where the pain was most frequent (F=3.15; pFDR=.029) and predicted widespread pain (T's>4.4, pFWE's<.045). Conversely, adolescents with JFM had increases in PCL/S1-thalamus (T=4.75, pFWE=.046) and PCL/S1-anterior insula rsFC (T=5.13, pFWE=.039).Reduced cortico-cortical sensory integration involving PCL/S1 and spanning the sensory systems may underly critical pain sensory features in youth with JFM. Reduced sensory integration is paralleled by augmented crosstalk between sensory and affective/salience-processing regions, potentially indicating a shift towards more affectively colored sensory experiences to the detriment of specific sensory discrimination. This article is protected by copyright. All rights reserved." @default.
- W4386407542 created "2023-09-05" @default.
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- W4386407542 date "2023-09-04" @default.
- W4386407542 modified "2023-10-18" @default.
- W4386407542 title "Reduced <scp>Cortico‐Cortical Resting‐State</scp> Connectivity in Sensory Systems is related to Bodily Pain in Juvenile Fibromyalgia" @default.
- W4386407542 doi "https://doi.org/10.1002/art.42691" @default.
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- W4386407542 hasPublicationYear "2023" @default.
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