Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386407568> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4386407568 endingPage "976" @default.
- W4386407568 startingPage "968" @default.
- W4386407568 abstract "Introduction A significant proportion of patients with carcinoid syndrome develop carcinoid heart disease (CHD). Valve degeneration can lead to right heart failure, and worsening prognosis. Replacement of affected valves is an effective therapy. We reviewed patients treated with valve replacement to assess prognostic factors. Methods CHD patients records who underwent valve replacement from 2003–2019 were reviewed. Results Twenty-six patients underwent valve replacement. Mean (SD) age was 61 (11) years, 54% female. Eleven tumours were grade G1, with the remaining G2. NYHA pre-surgery mean (SD) 2.0 (0.7); post-surgery mean 1.2; follow-up mean (SD) 1.6 (0.8). Mean NYHA score difference from pre- to post-surgery –0.71 ( P = 0.002). 88.5% two (PR & TR), 3.9% one, 3.9% three and 3.9% four valves replaced. 13 patients received Lu177 oxodotreotide; 27% completed four cycles. Mortality at 1 and 5 years follow up was 42% and 50% respectively. Cox proportional hazards model of survival from surgery, adjusting for age [hazard ratio (HR) 0.96 (0.89–1.03) ( P = 0.25)], four cycles of Lu177 oxodotreotide demonstrated HR 0.087 (0.0079–0.95) ( P = 0.045) indicating improved survival. Discussion Surgical patients were often NYHA grade II, and symptoms improved post-surgery. Four cycles of Lu177 oxodotreotide improved survival, although the confidence interval was wide. Further studies should be performed to assess Lu177 oxodotreotide in CHD." @default.
- W4386407568 created "2023-09-05" @default.
- W4386407568 creator A5002464694 @default.
- W4386407568 creator A5004351943 @default.
- W4386407568 creator A5006566227 @default.
- W4386407568 creator A5009110738 @default.
- W4386407568 creator A5012321663 @default.
- W4386407568 creator A5035140274 @default.
- W4386407568 creator A5042494371 @default.
- W4386407568 creator A5048208263 @default.
- W4386407568 creator A5057573280 @default.
- W4386407568 creator A5068915524 @default.
- W4386407568 creator A5086313602 @default.
- W4386407568 date "2023-09-04" @default.
- W4386407568 modified "2023-10-14" @default.
- W4386407568 title "Improving outcomes in carcinoid heart disease – learning from a single centre" @default.
- W4386407568 cites W2014254234 @default.
- W4386407568 cites W2061868495 @default.
- W4386407568 cites W2063178653 @default.
- W4386407568 cites W2154488948 @default.
- W4386407568 cites W2165062498 @default.
- W4386407568 cites W2509733292 @default.
- W4386407568 cites W2546786494 @default.
- W4386407568 cites W2592950930 @default.
- W4386407568 cites W2598918446 @default.
- W4386407568 cites W2603682043 @default.
- W4386407568 cites W2663808291 @default.
- W4386407568 cites W2763813381 @default.
- W4386407568 cites W2952436116 @default.
- W4386407568 cites W3007856372 @default.
- W4386407568 cites W3021056248 @default.
- W4386407568 cites W3135206799 @default.
- W4386407568 doi "https://doi.org/10.1097/mnm.0000000000001749" @default.
- W4386407568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37661777" @default.
- W4386407568 hasPublicationYear "2023" @default.
- W4386407568 type Work @default.
- W4386407568 citedByCount "0" @default.
- W4386407568 crossrefType "journal-article" @default.
- W4386407568 hasAuthorship W4386407568A5002464694 @default.
- W4386407568 hasAuthorship W4386407568A5004351943 @default.
- W4386407568 hasAuthorship W4386407568A5006566227 @default.
- W4386407568 hasAuthorship W4386407568A5009110738 @default.
- W4386407568 hasAuthorship W4386407568A5012321663 @default.
- W4386407568 hasAuthorship W4386407568A5035140274 @default.
- W4386407568 hasAuthorship W4386407568A5042494371 @default.
- W4386407568 hasAuthorship W4386407568A5048208263 @default.
- W4386407568 hasAuthorship W4386407568A5057573280 @default.
- W4386407568 hasAuthorship W4386407568A5068915524 @default.
- W4386407568 hasAuthorship W4386407568A5086313602 @default.
- W4386407568 hasConcept C126322002 @default.
- W4386407568 hasConcept C141071460 @default.
- W4386407568 hasConcept C164705383 @default.
- W4386407568 hasConcept C207103383 @default.
- W4386407568 hasConcept C2778198053 @default.
- W4386407568 hasConcept C2780007028 @default.
- W4386407568 hasConcept C2780026749 @default.
- W4386407568 hasConcept C2781151469 @default.
- W4386407568 hasConcept C2909397035 @default.
- W4386407568 hasConcept C44249647 @default.
- W4386407568 hasConcept C50382708 @default.
- W4386407568 hasConcept C71924100 @default.
- W4386407568 hasConceptScore W4386407568C126322002 @default.
- W4386407568 hasConceptScore W4386407568C141071460 @default.
- W4386407568 hasConceptScore W4386407568C164705383 @default.
- W4386407568 hasConceptScore W4386407568C207103383 @default.
- W4386407568 hasConceptScore W4386407568C2778198053 @default.
- W4386407568 hasConceptScore W4386407568C2780007028 @default.
- W4386407568 hasConceptScore W4386407568C2780026749 @default.
- W4386407568 hasConceptScore W4386407568C2781151469 @default.
- W4386407568 hasConceptScore W4386407568C2909397035 @default.
- W4386407568 hasConceptScore W4386407568C44249647 @default.
- W4386407568 hasConceptScore W4386407568C50382708 @default.
- W4386407568 hasConceptScore W4386407568C71924100 @default.
- W4386407568 hasIssue "11" @default.
- W4386407568 hasLocation W43864075681 @default.
- W4386407568 hasLocation W43864075682 @default.
- W4386407568 hasOpenAccess W4386407568 @default.
- W4386407568 hasPrimaryLocation W43864075681 @default.
- W4386407568 hasRelatedWork W1875140348 @default.
- W4386407568 hasRelatedWork W1993333140 @default.
- W4386407568 hasRelatedWork W2080860335 @default.
- W4386407568 hasRelatedWork W2619843640 @default.
- W4386407568 hasRelatedWork W2659989079 @default.
- W4386407568 hasRelatedWork W2782219009 @default.
- W4386407568 hasRelatedWork W4242038072 @default.
- W4386407568 hasRelatedWork W4311469719 @default.
- W4386407568 hasRelatedWork W4323033460 @default.
- W4386407568 hasRelatedWork W2288645155 @default.
- W4386407568 hasVolume "44" @default.
- W4386407568 isParatext "false" @default.
- W4386407568 isRetracted "false" @default.
- W4386407568 workType "article" @default.