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- W4386408022 abstract "Aims: To investigate the distribution and toxicity of ruthenium nanoparticles (Ru NPs) injected intravenously in mice. Methods: We synthesized Ru NPs, followed their biodistribution by x-ray fluorescence (XRF) imaging and evaluated organ toxicity by histopathology and gene expression. Results: Ru NPs accumulated, mainly in liver and spleen, where they were phagocyted by tissue macrophages, giving a transient inflammation and oxidative stress response that declined after 2 weeks. Ru NPs gradually accumulated in the skin, which was confirmed by microscopic examination of skin biopsies. Conclusion: Ru NP toxicity in recipient organs is transient. Particles are at least partially excreted by the skin, supporting a role for the skin as a nanoparticle clearing organ." @default.
- W4386408022 created "2023-09-05" @default.
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- W4386408022 date "2023-08-01" @default.
- W4386408022 modified "2023-10-17" @default.
- W4386408022 title "Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored <i>in vivo</i> by x-ray fluorescence" @default.
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- W4386408022 doi "https://doi.org/10.2217/nnm-2023-0061" @default.
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