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• W4386408780 abstract "Antibiotic resistance development and pathogen cross-dissemination are both considered essential risks to human health on a worldwide scale. Antimicrobial resistance genes (AMRs) are acquired, expressed, disseminated, and traded mainly through integrons, the key players capable of transferring genes from bacterial chromosomes to plasmids and their integration by integrase to the target pathogenic host. Moreover, integrons play a central role in disseminating and assembling genes connected with antibiotic resistance in pathogenic and commensal bacterial species. They exhibit a large and concealed diversity in the natural environment, raising concerns about their potential for comprehensive application in bacterial adaptation. They should be viewed as a dangerous pool of resistance determinants from the One Health approach. Among the three documented classes of integrons reported viz., class-1, 2, and 3, class 1 has been found frequently associated with AMRs in humans and is a critical genetic element to serve as a target for therapeutics to AMRs through gene silencing or combinatorial therapies. The direct method of screening gene cassettes linked to pathogenesis and resistance harbored by integrons is a novel way to assess human health. In the last decade, they have witnessed surveying the integron-associated gene cassettes associated with increased drug tolerance and rising pathogenicity of human pathogenic microbes. Consequently, we aimed to unravel the structure and functions of integrons and their integration mechanism by understanding horizontal gene transfer from one trophic group to another. Many updates for the gene cassettes harbored by integrons related to resistance and pathogenicity are extensively explored. Additionally, an updated account of the assessment of AMRs and prevailing antibiotic resistance by integrons in humans is grossly detailed-lastly, the estimation of AMR dissemination by employing integrons as potential biomarkers are also highlighted. The current review on integrons will pave the way to clinical understanding for devising a roadmap solution to AMR and pathogenicity. Graphical AbstractThe graphical abstract displays how integron-aided AMRs to humans: Transposons capture integron gene cassettes to yield high mobility integrons that target res sites of plasmids. These plasmids, in turn, promote the mobility of acquired integrons into diverse bacterial species. The acquisitions of resistant genes are transferred to humans through horizontal gene transfer." @default.
• W4386408780 created "2023-09-05" @default.
• W4386408780 creator A5002622667 @default.
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• W4386408780 creator A5036948334 @default.
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• W4386408780 creator A5084019473 @default.
• W4386408780 date "2023-08-31" @default.
• W4386408780 modified "2023-10-02" @default.
• W4386408780 title "Integrons in the development of antimicrobial resistance: critical review and perspectives" @default.
• W4386408780 cites W1655263842 @default.
• W4386408780 cites W1691012859 @default.
• W4386408780 cites W1830688004 @default.
• W4386408780 cites W1834117603 @default.
• W4386408780 cites W1885110740 @default.
• W4386408780 cites W1911549946 @default.
• W4386408780 cites W1964159659 @default.
• W4386408780 cites W1970959262 @default.
• W4386408780 cites W1972548672 @default.
• W4386408780 cites W1973641377 @default.
• W4386408780 cites W1974876474 @default.
• W4386408780 cites W1977980938 @default.
• W4386408780 cites W1978569811 @default.
• W4386408780 cites W1980292553 @default.
• W4386408780 cites W1982479612 @default.
• W4386408780 cites W1983065493 @default.
• W4386408780 cites W1986738579 @default.
• W4386408780 cites W1988158514 @default.
• W4386408780 cites W1990524884 @default.
• W4386408780 cites W1991072331 @default.
• W4386408780 cites W1997154183 @default.
• W4386408780 cites W2000175834 @default.
• W4386408780 cites W2009690857 @default.
• W4386408780 cites W2011210667 @default.
• W4386408780 cites W2019399596 @default.
• W4386408780 cites W2024236935 @default.
• W4386408780 cites W2028252303 @default.
• W4386408780 cites W2028789388 @default.
• W4386408780 cites W2029071234 @default.
• W4386408780 cites W2032879359 @default.
• W4386408780 cites W2034302623 @default.
• W4386408780 cites W2037470605 @default.
• W4386408780 cites W2039453294 @default.
• W4386408780 cites W2043134034 @default.
• W4386408780 cites W2043517428 @default.
• W4386408780 cites W2047606370 @default.
• W4386408780 cites W2050116248 @default.
• W4386408780 cites W2056294949 @default.
• W4386408780 cites W2058729834 @default.
• W4386408780 cites W2060954415 @default.
• W4386408780 cites W2062017322 @default.
• W4386408780 cites W2062791733 @default.
• W4386408780 cites W2063397465 @default.
• W4386408780 cites W2064983847 @default.
• W4386408780 cites W2065583132 @default.
• W4386408780 cites W2068371158 @default.
• W4386408780 cites W2071057327 @default.
• W4386408780 cites W2077075511 @default.
• W4386408780 cites W2077997909 @default.
• W4386408780 cites W2080347405 @default.
• W4386408780 cites W2085610803 @default.
• W4386408780 cites W2088917620 @default.
• W4386408780 cites W2099004335 @default.
• W4386408780 cites W2099423367 @default.
• W4386408780 cites W2105963295 @default.
• W4386408780 cites W2107121927 @default.
• W4386408780 cites W2113828015 @default.
• W4386408780 cites W2114517004 @default.
• W4386408780 cites W2115590956 @default.
• W4386408780 cites W2118701853 @default.
• W4386408780 cites W2119209016 @default.
• W4386408780 cites W2123391481 @default.
• W4386408780 cites W2126278335 @default.
• W4386408780 cites W2126977508 @default.
• W4386408780 cites W2129120358 @default.
• W4386408780 cites W2130932058 @default.
• W4386408780 cites W2131507767 @default.
• W4386408780 cites W2133829159 @default.
• W4386408780 cites W2135940253 @default.
• W4386408780 cites W2136317909 @default.
• W4386408780 cites W2137695414 @default.
• W4386408780 cites W2138332307 @default.
• W4386408780 cites W2138811562 @default.
• W4386408780 cites W2138886501 @default.
• W4386408780 cites W2138952930 @default.
• W4386408780 cites W2140623825 @default.
• W4386408780 cites W2141939691 @default.
• W4386408780 cites W2143014410 @default.
• W4386408780 cites W2144203006 @default.
• W4386408780 cites W2145580883 @default.
• W4386408780 cites W2151413158 @default.
• W4386408780 cites W2151459655 @default.
• W4386408780 cites W2154488171 @default.
• W4386408780 cites W2162825747 @default.
• W4386408780 cites W2163598737 @default.
• W4386408780 cites W2163852138 @default.
• W4386408780 cites W2165012009 @default.
• W4386408780 cites W2165991316 @default.

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