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- W4386410070 abstract "Birds can bioaccumulate persistent contaminants, and maternal transfer to eggs may expose embryos to concentrations sufficient to cause adverse effects during sensitive early-life stages. However, using tissue residue concentrations alone to infer whether contaminant effects are occurring suffers from uncertainty, and efficient, sensitive biomarkers remain limited in wildlife. We studied relationships between whole embryo contaminant concentrations (total mercury, organochlorine pesticides, perfluoroalkyl substances, polychlorinated biphenyls, and halogenated flame retardants) together with mRNA expression in embryonic liver tissue from a Pacific Ocean seabird, the rhinoceros auklet (Cerorhinca monocerata). Fresh eggs were collected, incubated under controlled conditions, and from the pre-hatch embryo, hepatic RNA was extracted for qPCR array analysis to measure gene expression (2−∆Cq), while the remaining embryo was analyzed for contaminant residues. Contaminant and gene expression data were assessed with a combination of multivariate approaches and linear models. Results indicated correlations between embryonic total mercury and several genes such as sepp1, which encodes selenoprotein P. Correlation between the biotransformation gene cyp1a4 and the C7 perfluoroalkyl carboxylic acid PFHpA was also evident. This study demonstrates that egg collection from free-living populations for contaminant biomonitoring programs can relate chemical residues to in ovo mRNA gene expression effects in embryo hepatic tissue." @default.
- W4386410070 created "2023-09-05" @default.
- W4386410070 creator A5008776471 @default.
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- W4386410070 date "2023-12-01" @default.
- W4386410070 modified "2023-10-02" @default.
- W4386410070 title "Contaminant biomonitoring augmented with a qPCR array indicates hepatic mRNA gene expression effects in wild-collected seabird embryos" @default.
- W4386410070 cites W1043028287 @default.
- W4386410070 cites W1195505006 @default.
- W4386410070 cites W1523050720 @default.
- W4386410070 cites W1575535935 @default.
- W4386410070 cites W1867139110 @default.
- W4386410070 cites W1973627481 @default.
- W4386410070 cites W1975439187 @default.
- W4386410070 cites W1977881360 @default.
- W4386410070 cites W1978328690 @default.
- W4386410070 cites W1978366290 @default.
- W4386410070 cites W1980077296 @default.
- W4386410070 cites W1985181883 @default.
- W4386410070 cites W1985286795 @default.
- W4386410070 cites W1990518165 @default.
- W4386410070 cites W1996929812 @default.
- W4386410070 cites W1999400864 @default.
- W4386410070 cites W2003098525 @default.
- W4386410070 cites W2021978625 @default.
- W4386410070 cites W2022204051 @default.
- W4386410070 cites W2031188909 @default.
- W4386410070 cites W2032112982 @default.
- W4386410070 cites W2040915552 @default.
- W4386410070 cites W2042135671 @default.
- W4386410070 cites W2044732314 @default.
- W4386410070 cites W2045814267 @default.
- W4386410070 cites W2046757425 @default.
- W4386410070 cites W2049429223 @default.
- W4386410070 cites W2053957993 @default.
- W4386410070 cites W2054174301 @default.
- W4386410070 cites W2055027948 @default.
- W4386410070 cites W2058829486 @default.
- W4386410070 cites W2064921674 @default.
- W4386410070 cites W2068419740 @default.
- W4386410070 cites W2070203531 @default.
- W4386410070 cites W2071984988 @default.
- W4386410070 cites W2074083862 @default.
- W4386410070 cites W2080394037 @default.
- W4386410070 cites W2085143050 @default.
- W4386410070 cites W2087577664 @default.
- W4386410070 cites W2089503232 @default.
- W4386410070 cites W2091187831 @default.
- W4386410070 cites W2091343301 @default.
- W4386410070 cites W2091392840 @default.
- W4386410070 cites W2107049615 @default.
- W4386410070 cites W2110385701 @default.
- W4386410070 cites W2114570899 @default.
- W4386410070 cites W2119289098 @default.
- W4386410070 cites W2126247577 @default.
- W4386410070 cites W2136856112 @default.
- W4386410070 cites W2140920072 @default.
- W4386410070 cites W2144699649 @default.
- W4386410070 cites W2151844491 @default.
- W4386410070 cites W2160528945 @default.
- W4386410070 cites W2168712788 @default.
- W4386410070 cites W2170257753 @default.
- W4386410070 cites W2268150323 @default.
- W4386410070 cites W2290030539 @default.
- W4386410070 cites W2325015995 @default.
- W4386410070 cites W2341775751 @default.
- W4386410070 cites W2343986412 @default.
- W4386410070 cites W2510285555 @default.
- W4386410070 cites W2554944435 @default.
- W4386410070 cites W2589710763 @default.
- W4386410070 cites W2605337732 @default.
- W4386410070 cites W2609910564 @default.
- W4386410070 cites W2734803963 @default.
- W4386410070 cites W2794032190 @default.
- W4386410070 cites W2800547942 @default.
- W4386410070 cites W2803096002 @default.
- W4386410070 cites W2808537400 @default.
- W4386410070 cites W2928834788 @default.
- W4386410070 cites W2947942168 @default.
- W4386410070 cites W2954766769 @default.
- W4386410070 cites W2955193846 @default.
- W4386410070 cites W3008817393 @default.
- W4386410070 cites W3030007675 @default.
- W4386410070 cites W3081160175 @default.
- W4386410070 cites W3094868529 @default.
- W4386410070 cites W3121199752 @default.
- W4386410070 cites W3124299196 @default.
- W4386410070 cites W3138296953 @default.
- W4386410070 cites W3152286416 @default.
- W4386410070 cites W3156660746 @default.
- W4386410070 cites W3161792626 @default.
- W4386410070 cites W4200386661 @default.