Matches in SemOpenAlex for { <https://semopenalex.org/work/W4386410604> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W4386410604 endingPage "191" @default.
- W4386410604 startingPage "184" @default.
- W4386410604 abstract "in rheumatoid arthritis (RA). Objectives: To evaluate the effect of different TNF inhibitors on plasma IL-6 levels and disease activity in RA patients. Methods: A longitudinal, observational study included 65 adult RA patients receiving TNF inhibitors for at least six weeks in Sulaymaniyah, Iraq, between February and August 2022. Disease activity was assessed using the disease activity score 28 (DAS28). Plasma IL-6 levels, CRP, and ESR were measured at two time points over 14 weeks during maintenance therapy. Results: After 14 weeks, adalimumab lowered IL-6 levels to 31.92 ng/L (0.24), ESR to 15 mm/hr (16.8), and CRP to 8.4 mg/L (26.2). DAS28/ESR was also improved, it went from 4.7 (1.2) to 4.0 (1.3), which was the biggest change. Infliximab decreased IL-6 31.87 ng/L (0.29), ESR 10.1 mm/hr (15.0), and CRP 7 mg/L (13.5), but the smallest improvement was in DAS28/ESR 4.6 (1.6) to 4.5 (1.2). Etanercept exhibited the lowest decrease in IL-6, ESR, and CRP: 31.77 ng/L (0.39), 7.5 mm/hr (6.5), and 4.9 mg/L (4.9), respectively. However, it showed the second-greatest median improvement in DAS28/ESR, from 4·4 (1·8) to 4·0 (1·4). No correlation was found between plasma IL-6 levels and DAS28/ESR at either time point. Conclusion: TNF inhibitors differ in reducing plasma IL-6 levels and DAS28 during maintenance therapy in RA patients. Adalimumab was the most effective in reducing IL-6, CRP, ESR levels, and DAS28." @default.
- W4386410604 created "2023-09-05" @default.
- W4386410604 creator A5030514156 @default.
- W4386410604 creator A5081815811 @default.
- W4386410604 date "2023-09-04" @default.
- W4386410604 modified "2023-10-01" @default.
- W4386410604 title "Interleukin-6 Suppression by Different TNF Inhibitors in Rheumatoid Arthritis Patients During Maintenance Therapy" @default.
- W4386410604 cites W1517146551 @default.
- W4386410604 cites W1967918376 @default.
- W4386410604 cites W2014664990 @default.
- W4386410604 cites W2024218526 @default.
- W4386410604 cites W2025222181 @default.
- W4386410604 cites W2064026395 @default.
- W4386410604 cites W2093120748 @default.
- W4386410604 cites W2101840353 @default.
- W4386410604 cites W2104669609 @default.
- W4386410604 cites W2105213577 @default.
- W4386410604 cites W2110177517 @default.
- W4386410604 cites W2124045236 @default.
- W4386410604 cites W2124312719 @default.
- W4386410604 cites W2127696180 @default.
- W4386410604 cites W2131553420 @default.
- W4386410604 cites W2155702314 @default.
- W4386410604 cites W2193504330 @default.
- W4386410604 cites W2200509731 @default.
- W4386410604 cites W2355702181 @default.
- W4386410604 cites W2516202125 @default.
- W4386410604 cites W2562770265 @default.
- W4386410604 cites W2621061076 @default.
- W4386410604 cites W2734551017 @default.
- W4386410604 cites W2742599938 @default.
- W4386410604 cites W2755547878 @default.
- W4386410604 cites W2806704569 @default.
- W4386410604 cites W2836422119 @default.
- W4386410604 cites W2889511105 @default.
- W4386410604 cites W3034100339 @default.
- W4386410604 cites W3042195389 @default.
- W4386410604 cites W3093014513 @default.
- W4386410604 cites W3093484026 @default.
- W4386410604 cites W3207160861 @default.
- W4386410604 cites W3216233453 @default.
- W4386410604 cites W4297909281 @default.
- W4386410604 cites W4362730825 @default.
- W4386410604 cites W4382792542 @default.
- W4386410604 doi "https://doi.org/10.54133/ajms.v5i.230" @default.
- W4386410604 hasPublicationYear "2023" @default.
- W4386410604 type Work @default.
- W4386410604 citedByCount "0" @default.
- W4386410604 crossrefType "journal-article" @default.
- W4386410604 hasAuthorship W4386410604A5030514156 @default.
- W4386410604 hasAuthorship W4386410604A5081815811 @default.
- W4386410604 hasBestOaLocation W43864106041 @default.
- W4386410604 hasConcept C126322002 @default.
- W4386410604 hasConcept C17991360 @default.
- W4386410604 hasConcept C2777138892 @default.
- W4386410604 hasConcept C2777226972 @default.
- W4386410604 hasConcept C2777575956 @default.
- W4386410604 hasConcept C2780132546 @default.
- W4386410604 hasConcept C71924100 @default.
- W4386410604 hasConcept C90924648 @default.
- W4386410604 hasConceptScore W4386410604C126322002 @default.
- W4386410604 hasConceptScore W4386410604C17991360 @default.
- W4386410604 hasConceptScore W4386410604C2777138892 @default.
- W4386410604 hasConceptScore W4386410604C2777226972 @default.
- W4386410604 hasConceptScore W4386410604C2777575956 @default.
- W4386410604 hasConceptScore W4386410604C2780132546 @default.
- W4386410604 hasConceptScore W4386410604C71924100 @default.
- W4386410604 hasConceptScore W4386410604C90924648 @default.
- W4386410604 hasLocation W43864106041 @default.
- W4386410604 hasOpenAccess W4386410604 @default.
- W4386410604 hasPrimaryLocation W43864106041 @default.
- W4386410604 hasRelatedWork W1555548379 @default.
- W4386410604 hasRelatedWork W1973470095 @default.
- W4386410604 hasRelatedWork W1976481621 @default.
- W4386410604 hasRelatedWork W1979251453 @default.
- W4386410604 hasRelatedWork W1993992685 @default.
- W4386410604 hasRelatedWork W2038285281 @default.
- W4386410604 hasRelatedWork W2141436693 @default.
- W4386410604 hasRelatedWork W2341567294 @default.
- W4386410604 hasRelatedWork W2416182167 @default.
- W4386410604 hasRelatedWork W4200063390 @default.
- W4386410604 hasVolume "5" @default.
- W4386410604 isParatext "false" @default.
- W4386410604 isRetracted "false" @default.
- W4386410604 workType "article" @default.